CGP1_SCHPO
ID CGP1_SCHPO Reviewed; 411 AA.
AC P87049; O13840; Q9HGI0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 3.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=G1/S-specific cyclin pas1;
GN Name=pas1; ORFNames=SPAC19E9.03, SPAC57A10.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10982385; DOI=10.1091/mbc.11.9.2845;
RA Tanaka K., Okayama H.;
RT "A pcl-like cyclin activates the Res2p-Cdc10p cell cycle 'start'
RT transcriptional factor complex in fission yeast.";
RL Mol. Biol. Cell 11:2845-2862(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Essential for the control of the cell cycle at the G1/S
CC (start) transition. Interacts with the pef1 protein kinase. The
CC pef1/pas1 complex activates the res2/cdc10 complex.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR EMBL; AB045126; BAB16401.1; -; mRNA.
DR EMBL; CU329670; CAC35180.1; -; Genomic_DNA.
DR PIR; T38928; T38928.
DR RefSeq; XP_001713050.1; XM_001712998.2.
DR AlphaFoldDB; P87049; -.
DR SMR; P87049; -.
DR BioGRID; 280482; 10.
DR STRING; 4896.SPAC19E9.03.1; -.
DR PaxDb; P87049; -.
DR EnsemblFungi; SPAC19E9.03.1; SPAC19E9.03.1:pep; SPAC19E9.03.
DR PomBase; SPAC19E9.03; pas1.
DR VEuPathDB; FungiDB:SPAC19E9.03; -.
DR eggNOG; KOG1674; Eukaryota.
DR HOGENOM; CLU_672946_0_0_1; -.
DR InParanoid; P87049; -.
DR OMA; VELNIME; -.
DR PRO; PR:P87049; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; ISO:PomBase.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:PomBase.
DR GO; GO:1905412; P:negative regulation of mitotic cohesin loading; IGI:PomBase.
DR GO; GO:1905589; P:positive regulation of L-arginine import across plasma membrane; IMP:PomBase.
DR GO; GO:1905534; P:positive regulation of leucine import across plasma membrane; IMP:PomBase.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IGI:PomBase.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IGI:PomBase.
DR GO; GO:0007165; P:signal transduction; IC:PomBase.
DR GO; GO:0007089; P:traversing start control point of mitotic cell cycle; IGI:PomBase.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR013922; Cyclin_PHO80-like.
DR PANTHER; PTHR15615; PTHR15615; 1.
DR Pfam; PF08613; Cyclin; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..411
FT /note="G1/S-specific cyclin pas1"
FT /id="PRO_0000080506"
FT REGION 210..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 45344 MW; E9A5B3C7F9227D62 CRC64;
MSKVNMRALL ESFSTVILSI YPLAKSTNQQ SHSHSLSLTQ FLYETIRRSR VDYTTLLLAL
YYFIRFRDAA SSKPTNYIPL LCGRRLFLVC LMAATKFLQD RSFSNRAWSR LSGLPVDKLL
VLEYMFYQCI DYRLVVPKHI FARWSLLVGE CCAHATARYD STDPNVASFG SVAQYWVSLF
SNVQSSLDDL FSIACLTKIA HRRMNANAAL KNQATRKPSS SPQTTQDSSP ILTMAPSTPV
SVGSTPPSTP SVLPIAKQLA PMNVCKAHIQ ASNQSRTLTT ASPPEQIPLM EPQVYVNPQV
LPGRLSSLSK PVSLPPTPSS PKVGVYRPMT SKSNGGVAYC YNAQKLNNAT GPVTFNMPFA
SVLPLAVSVS CDLGTASAYV ASLPQPCSQK RHLEEDYSCL TEHSAKRRSY F
