CGR1_ASPFU
ID CGR1_ASPFU Reviewed; 114 AA.
AC Q9HEQ8; Q4WBL8;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=rRNA-processing protein cgrA;
GN Name=cgrA; Synonyms=cgr1; ORFNames=AFUA_8G02750;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11798057; DOI=10.1080/mmy.39.6.517.521;
RA Boettner D., Huebner N., Rhodes J.C., Askew D.S.;
RT "Molecular cloning of Aspergillus fumigatus CgrA, the ortholog of a
RT conserved fungal nucleolar protein.";
RL Med. Mycol. 39:517-521(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in nucleolar integrity and required for processing
CC of the pre-rRNA for the 60S ribosome subunit. {ECO:0000250,
CC ECO:0000269|PubMed:11798057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11798057}.
CC -!- SIMILARITY: Belongs to the CGR1 family. {ECO:0000305}.
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DR EMBL; AY008837; AAG28884.1; -; mRNA.
DR EMBL; AAHF01000014; EAL84894.1; -; Genomic_DNA.
DR RefSeq; XP_746932.1; XM_741839.1.
DR AlphaFoldDB; Q9HEQ8; -.
DR SMR; Q9HEQ8; -.
DR STRING; 746128.CADAFUBP00008161; -.
DR EnsemblFungi; EAL84894; EAL84894; AFUA_8G02750.
DR GeneID; 3504434; -.
DR KEGG; afm:AFUA_8G02750; -.
DR eggNOG; ENOG502S7VB; Eukaryota.
DR HOGENOM; CLU_125051_0_0_1; -.
DR InParanoid; Q9HEQ8; -.
DR OMA; NGKQWHD; -.
DR OrthoDB; 1625085at2759; -.
DR PHI-base; PHI:335; -.
DR Proteomes; UP000002530; Chromosome 8.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR005579; Cgr1-like.
DR Pfam; PF03879; Cgr1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..114
FT /note="rRNA-processing protein cgrA"
FT /id="PRO_0000278946"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..101
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..114
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 114 AA; 13779 MW; FF7618FAC2CA4BD8 CRC64;
MSSAIPTSSV NPVKGMRKNG KNWHDSKKPF RPTSGLTSYE KRLEARKRQE AVKEHERELR
EEKEAERKAQ IQKIKDRRAA KEEKERYEKM AEKMHRKRVE RLKRREKRNK LLHS
