ID   ACDH1_MYCVP             Reviewed;         315 AA.
AC   A1T2N5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Probable inactive acetaldehyde dehydrogenase 1;
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating] 1;
GN   OrderedLocusNames=Mvan_0596;
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01657, ECO:0000305}.
CC   -!- CAUTION: In contrast to other members of the family, lacks the
CC       conserved Cys active site in position 129, suggesting it is inactive.
CC       {ECO:0000305}.
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DR   EMBL; CP000511; ABM11435.1; -; Genomic_DNA.
DR   RefSeq; WP_011777872.1; NC_008726.1.
DR   AlphaFoldDB; A1T2N5; -.
DR   SMR; A1T2N5; -.
DR   STRING; 350058.Mvan_0596; -.
DR   EnsemblBacteria; ABM11435; ABM11435; Mvan_0596.
DR   KEGG; mva:Mvan_0596; -.
DR   eggNOG; COG4569; Bacteria.
DR   HOGENOM; CLU_062208_0_0_11; -.
DR   OMA; IPAYAGN; -.
DR   OrthoDB; 1432332at2; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01657; Ac_ald_DH_ac; 1.
DR   InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR   InterPro; IPR015426; Acetylaldehyde_DH_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
KW   NAD; Reference proteome.
FT   CHAIN           1..315
FT                   /note="Probable inactive acetaldehyde dehydrogenase 1"
FT                   /id="PRO_0000387692"
FT   BINDING         14..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT   BINDING         288
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
SQ   SEQUENCE   315 AA;  32447 MW;  FB1244453D032A8F CRC64;
     MTPTVKCPVA ILGSGDVGTD LMMKILRSDG PLTVGALVGL DPEPGGLARA ERLGVPTSAA
     GIDGLPAMPE FGDIGIVFDA TPAGAPRAEL EKAGVCVLDL NPAVVGPHCV PAVNLEDHLD
     TPNLNLVTGA GQATVPIVAA VGRVGAVSYA ETVTSVAAKS ADPATRANID ESIETTTAAL
     RTVGGARRAR SIFIINPADP PILMRNTVYC LVDGDVPRGD IEQSIAAMVE RVTSYVPGYR
     LKQRVQFETF TATDPLHIPE TGGFTGTRVT VLVEVTAGEP HLPGYAGNLE MMTSAAKAAA
     ERIALHRSRT AGAAT