ID   CGR1_COCIM              Reviewed;         130 AA.
AC   Q1E554; J3KLG0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=rRNA-processing protein CGR1;
GN   Name=CGR1; ORFNames=CIMG_02309;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in nucleolar integrity and required for processing
CC       of the pre-rRNA for the 60S ribosome subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CGR1 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS36955.3; -; Genomic_DNA.
DR   RefSeq; XP_001248538.1; XM_001248537.2.
DR   AlphaFoldDB; Q1E554; -.
DR   SMR; Q1E554; -.
DR   STRING; 246410.Q1E554; -.
DR   EnsemblFungi; EAS36955; EAS36955; CIMG_02309.
DR   GeneID; 4566752; -.
DR   KEGG; cim:CIMG_02309; -.
DR   VEuPathDB; FungiDB:CIMG_02309; -.
DR   InParanoid; Q1E554; -.
DR   OMA; NGKQWHD; -.
DR   OrthoDB; 1643480at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR005579; Cgr1-like.
DR   Pfam; PF03879; Cgr1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..130
FT                   /note="rRNA-processing protein CGR1"
FT                   /id="PRO_0000278952"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          58..118
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        91..111
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..130
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   130 AA;  15013 MW;  8EA1EB5916859C7F CRC64;
     MSSTEPAPAP APEPAPAPAA APAAAAAAPK GMRKNGKNWH DVKTPFRPTK GQTSYARRLE
     ERKAMAAIKE KEKEMKEEKE AERQRRIQAI KDRRAAKEEK ERYEKMAEKM HRKRVERRKR
     REKRNKLLNS