ID   CGR1_CRYNJ              Reviewed;         127 AA.
AC   P0CM66; Q55SP5; Q5KH33;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=rRNA-processing protein CGR1;
GN   Name=CGR1; OrderedLocusNames=CNE01440;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in nucleolar integrity and required for processing
CC       of the pre-rRNA for the 60S ribosome subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CGR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017345; AAW43439.1; -; Genomic_DNA.
DR   RefSeq; XP_570746.1; XM_570746.1.
DR   AlphaFoldDB; P0CM66; -.
DR   SMR; P0CM66; -.
DR   STRING; 5207.AAW43439; -.
DR   PaxDb; P0CM66; -.
DR   EnsemblFungi; AAW43439; AAW43439; CNE01440.
DR   GeneID; 3257652; -.
DR   KEGG; cne:CNE01440; -.
DR   VEuPathDB; FungiDB:CNE01440; -.
DR   eggNOG; ENOG502SCS3; Eukaryota.
DR   HOGENOM; CLU_125051_1_0_1; -.
DR   InParanoid; P0CM66; -.
DR   OMA; NGKQWHD; -.
DR   OrthoDB; 1601122at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR005579; Cgr1-like.
DR   Pfam; PF03879; Cgr1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..127
FT                   /note="rRNA-processing protein CGR1"
FT                   /id="PRO_0000278953"
FT   REGION          1..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          52..114
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..127
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   127 AA;  14530 MW;  16DC3E38566FD7A8 CRC64;
     MSAEPSSSAQ ASAPTVVSVA PSKNGRTPGK AHKSAKTALR RSYISPSVKT PFEKRMEKEK
     AQQAAKQLEK ELKEEKENER QRKVNIIKER RARKEEKQRE EELRAKMSAK KLQRMKKREG
     RSKKING