ID   CGRF1_MOUSE             Reviewed;         332 AA.
AC   Q8BMJ7; Q3U3F1; Q8CI24;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Cell growth regulator with RING finger domain protein 1;
DE   AltName: Full=Cell growth regulatory gene 19 protein;
GN   Name=Cgrrf1; Synonyms=Cgr19;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Able to inhibit growth in several cell lines.
CC       {ECO:0000250|UniProtKB:P97587}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99675}.
CC       Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99675}.
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DR   EMBL; AK030755; BAC27121.1; -; mRNA.
DR   EMBL; AK154797; BAE32835.1; -; mRNA.
DR   EMBL; BC037677; AAH37677.1; -; mRNA.
DR   CCDS; CCDS26981.1; -.
DR   RefSeq; NP_081108.2; NM_026832.3.
DR   RefSeq; XP_006519548.1; XM_006519485.3.
DR   AlphaFoldDB; Q8BMJ7; -.
DR   SMR; Q8BMJ7; -.
DR   BioGRID; 213033; 1.
DR   IntAct; Q8BMJ7; 1.
DR   MINT; Q8BMJ7; -.
DR   STRING; 10090.ENSMUSP00000070548; -.
DR   iPTMnet; Q8BMJ7; -.
DR   PhosphoSitePlus; Q8BMJ7; -.
DR   MaxQB; Q8BMJ7; -.
DR   PaxDb; Q8BMJ7; -.
DR   PRIDE; Q8BMJ7; -.
DR   ProteomicsDB; 281118; -.
DR   Antibodypedia; 152; 171 antibodies from 30 providers.
DR   DNASU; 68755; -.
DR   Ensembl; ENSMUST00000068532; ENSMUSP00000070548; ENSMUSG00000055128.
DR   GeneID; 68755; -.
DR   KEGG; mmu:68755; -.
DR   UCSC; uc007thj.1; mouse.
DR   CTD; 10668; -.
DR   MGI; MGI:1916368; Cgrrf1.
DR   VEuPathDB; HostDB:ENSMUSG00000055128; -.
DR   eggNOG; KOG4265; Eukaryota.
DR   GeneTree; ENSGT00390000004542; -.
DR   HOGENOM; CLU_053217_0_0_1; -.
DR   InParanoid; Q8BMJ7; -.
DR   OMA; EDNREIY; -.
DR   OrthoDB; 670633at2759; -.
DR   PhylomeDB; Q8BMJ7; -.
DR   TreeFam; TF328102; -.
DR   BioGRID-ORCS; 68755; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Cgrrf1; mouse.
DR   PRO; PR:Q8BMJ7; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8BMJ7; protein.
DR   Bgee; ENSMUSG00000055128; Expressed in gastrocnemius medialis and 227 other tissues.
DR   ExpressionAtlas; Q8BMJ7; baseline and differential.
DR   Genevisible; Q8BMJ7; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR042496; CGRF1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR15379; PTHR15379; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Endoplasmic reticulum; Growth arrest; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..332
FT                   /note="Cell growth regulator with RING finger domain
FT                   protein 1"
FT                   /id="PRO_0000055870"
FT   ZN_FING         274..309
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   CONFLICT        82..83
FT                   /note="TG -> S (in Ref. 2; AAH37677)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  37899 MW;  5012EE360929ECC1 CRC64;
     MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET QFSTRAFKKQ
     MRQVKNPFGL EITNSSAASL ATGMALRTDC LEDSRLTCYW GCSVQKLYEA LQKHAYCFRI
     STPQALEEAL YSDYLHREQY FIKKHSKEEI YCQLPSDTEI EDFGPVPRSR YPLVALLTLA
     DEDDREIYDI ISMVSVIHIP DKTYKLPCRI LYQYLILAQG QFYDLKQLFM SANNSPPPSN
     DESPEDRSVE QSLLEKVGLA GNDGDPVEES SRDCVVCQNG GVNWVLLPCR HACLCDSCVR
     YFKQCPMCRQ FVQESFALCG QKEPDKDLLE TS