ID   CGRF1_RAT               Reviewed;         332 AA.
AC   P97587;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Cell growth regulator with RING finger domain protein 1;
DE   AltName: Full=Cell growth regulatory gene 19 protein;
GN   Name=Cgrrf1; Synonyms=Cgr19;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Fischer; TISSUE=Fibroblast;
RX   PubMed=8968090;
RA   Madden S.L., Galella E.A., Riley D., Bertelsen A.H., Beaudry G.A.;
RT   "Induction of cell growth regulatory genes by p53.";
RL   Cancer Res. 56:5384-5390(1996).
CC   -!- FUNCTION: Able to inhibit growth in several cell lines.
CC       {ECO:0000269|PubMed:8968090}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99675}.
CC       Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99675}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis, lower levels of
CC       expression is seen in skeletal muscle, liver, lung and brain.
CC       {ECO:0000269|PubMed:8968090}.
CC   -!- INDUCTION: By p53. {ECO:0000269|PubMed:8968090}.
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DR   EMBL; U66471; AAC52951.1; -; mRNA.
DR   RefSeq; NP_446351.1; NM_053899.1.
DR   AlphaFoldDB; P97587; -.
DR   SMR; P97587; -.
DR   STRING; 10116.ENSRNOP00000013912; -.
DR   iPTMnet; P97587; -.
DR   PhosphoSitePlus; P97587; -.
DR   PaxDb; P97587; -.
DR   GeneID; 116679; -.
DR   KEGG; rno:116679; -.
DR   CTD; 10668; -.
DR   RGD; 620803; Cgrrf1.
DR   eggNOG; KOG4265; Eukaryota.
DR   InParanoid; P97587; -.
DR   OrthoDB; 670633at2759; -.
DR   PhylomeDB; P97587; -.
DR   PRO; PR:P97587; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030308; P:negative regulation of cell growth; IDA:RGD.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR042496; CGRF1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR15379; PTHR15379; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Endoplasmic reticulum; Growth arrest; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..332
FT                   /note="Cell growth regulator with RING finger domain
FT                   protein 1"
FT                   /id="PRO_0000055871"
FT   ZN_FING         274..309
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   332 AA;  37443 MW;  D918EC9B74885104 CRC64;
     MAAVFLVTLY EYSPLFYIAV VFTCFIATTG LVLGWLGWDV PVILRNSEET QFSTRAFKKQ
     MRQVKNPFGL EITNSSAASL ATGVTLTTDC LEDSRLTCYW GCSVQKLYEA LQKHVYCFRI
     STPQALEEAL YSDYLHREQY FIKKHSKEEI YCQLPSSTGV EDFGPVPRSR YPLVALLTLA
     DEDDREIYDI ISMVSVIHIP DKTYKLPCRI LYQYLILAQG QFYDLKQLFM SANNSATPSR
     DQSPADGSVE HSLLEKAGLA GAEVDPVEES SKDCVVCQNG GVNWVLLPCR HACLCDSCVC
     YFKQCPMCRQ FVQESFALCG QKEADKDILE TS