CGS6_YEAST
ID CGS6_YEAST Reviewed; 380 AA.
AC P32943; D6VUP0;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=S-phase entry cyclin-6;
GN Name=CLB6; OrderedLocusNames=YGR109C; ORFNames=G5970;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K1107;
RX PubMed=8319908; DOI=10.1101/gad.7.7a.1160;
RA Schwob E., Nasmyth K.;
RT "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in
RT Saccharomyces cerevisiae.";
RL Genes Dev. 7:1160-1175(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8253070; DOI=10.1002/j.1460-2075.1993.tb06018.x;
RA Kuehne C., Linder P.;
RT "A new pair of B-type cyclins from Saccharomyces cerevisiae that function
RT early in the cell cycle.";
RL EMBO J. 12:3437-3447(1993).
RN [3]
RP SEQUENCE REVISION TO C-TERMINUS.
RA Kuehne C.;
RL Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8905931;
RX DOI=10.1002/(sici)1097-0061(19960930)12:12<1273::aid-yea21>3.0.co;2-j;
RA Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R.,
RA Schreer A., Schaefer B., Zimmermann M., Wolf K.;
RT "The sequence of a 23.4 kb segment on the right arm of chromosome VII from
RT Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3
RT element and 11 new open reading frames.";
RL Yeast 12:1273-1277(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- FUNCTION: Involved in G1/S and or S phase progression. Interacts with
CC CDC28.
CC -!- INTERACTION:
CC P32943; P00546: CDC28; NbExp=3; IntAct=EBI-2049771, EBI-4253;
CC -!- DEVELOPMENTAL STAGE: Maximally expressed just before cell cycle start.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; X70436; CAA49894.1; -; Genomic_DNA.
DR EMBL; X72890; CAA51408.1; -; Genomic_DNA.
DR EMBL; Z72894; CAA97113.1; -; Genomic_DNA.
DR EMBL; AY693095; AAT93114.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08201.1; -; Genomic_DNA.
DR PIR; S64417; S64417.
DR RefSeq; NP_011623.3; NM_001181238.3.
DR AlphaFoldDB; P32943; -.
DR SMR; P32943; -.
DR BioGRID; 33353; 97.
DR ComplexPortal; CPX-339; CLB6-CDC28 kinase complex.
DR IntAct; P32943; 8.
DR MINT; P32943; -.
DR STRING; 4932.YGR109C; -.
DR iPTMnet; P32943; -.
DR PaxDb; P32943; -.
DR PRIDE; P32943; -.
DR EnsemblFungi; YGR109C_mRNA; YGR109C; YGR109C.
DR GeneID; 853003; -.
DR KEGG; sce:YGR109C; -.
DR SGD; S000003341; CLB6.
DR VEuPathDB; FungiDB:YGR109C; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000176489; -.
DR HOGENOM; CLU_020695_12_4_1; -.
DR InParanoid; P32943; -.
DR OMA; ENSKWDE; -.
DR BioCyc; YEAST:G3O-30818-MON; -.
DR Reactome; R-SCE-3214858; RMTs methylate histone arginines.
DR Reactome; R-SCE-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-6804757; Regulation of TP53 Degradation.
DR Reactome; R-SCE-68949; Orc1 removal from chromatin.
DR Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-SCE-69202; Cyclin E associated events during G1/S transition.
DR Reactome; R-SCE-69231; Cyclin D associated events in G1.
DR Reactome; R-SCE-69656; Cyclin A:Cdk2-associated events at S phase entry.
DR Reactome; R-SCE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-SCE-9754119; Drug-mediated inhibition of CDK4/CDK6 activity.
DR Reactome; R-SCE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:P32943; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P32943; protein.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:SGD.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0045740; P:positive regulation of DNA replication; IGI:SGD.
DR GO; GO:0006279; P:premeiotic DNA replication; IMP:SGD.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:SGD.
DR GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:ComplexPortal.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..380
FT /note="S-phase entry cyclin-6"
FT /id="PRO_0000080409"
FT REGION 63..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 77
FT /note="T -> S (in Ref. 2; CAA51408)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="P -> S (in Ref. 2; CAA51408)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="I -> M (in Ref. 2; CAA51408)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="F -> L (in Ref. 1; CAA49894)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 44145 MW; C8A4284091C64F87 CRC64;
MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS EVNSNKIDSL
QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC HQWKNLDSIE MDDPFMVAEY
TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH LKSSMRALLI DWLVEVHEKF HCLPETLFLA
INLLDRFLSQ NVVKLNKLQL LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE
LFVLSSLGYN ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA
MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD TNLDSLRLKY
KKPKHGMVYF KVFDWCKQKR
