CH034_MOUSE
ID CH034_MOUSE Reviewed; 459 AA.
AC Q8BZJ8; Q3UVZ9; Q8BJN6; Q8BUZ5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Uncharacterized protein C8orf34 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-459 (ISOFORM 4).
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, Diencephalon, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8BZJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZJ8-2; Sequence=VSP_033018, VSP_033020;
CC Name=3;
CC IsoId=Q8BZJ8-3; Sequence=VSP_033016, VSP_033017;
CC Name=4;
CC IsoId=Q8BZJ8-4; Sequence=VSP_033019, VSP_033021;
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DR EMBL; AK034391; BAC28694.1; -; mRNA.
DR EMBL; AK081222; BAC38170.1; -; mRNA.
DR EMBL; AK081622; BAC38273.1; -; mRNA.
DR EMBL; AK136763; BAE23120.1; -; mRNA.
DR CCDS; CCDS35513.1; -. [Q8BZJ8-1]
DR CCDS; CCDS48218.1; -. [Q8BZJ8-4]
DR CCDS; CCDS48220.1; -. [Q8BZJ8-2]
DR RefSeq; NP_001153841.1; NM_001160369.2.
DR RefSeq; NP_001153842.1; NM_001160370.2. [Q8BZJ8-2]
DR RefSeq; NP_001153843.1; NM_001160371.2. [Q8BZJ8-4]
DR RefSeq; NP_001297380.1; NM_001310451.1.
DR RefSeq; NP_796147.2; NM_177173.6. [Q8BZJ8-1]
DR AlphaFoldDB; Q8BZJ8; -.
DR SMR; Q8BZJ8; -.
DR BioGRID; 236065; 1.
DR STRING; 10090.ENSMUSP00000117421; -.
DR iPTMnet; Q8BZJ8; -.
DR PhosphoSitePlus; Q8BZJ8; -.
DR jPOST; Q8BZJ8; -.
DR PaxDb; Q8BZJ8; -.
DR PRIDE; Q8BZJ8; -.
DR Antibodypedia; 25036; 69 antibodies from 17 providers.
DR Ensembl; ENSMUST00000048613; ENSMUSP00000043857; ENSMUSG00000057715. [Q8BZJ8-1]
DR Ensembl; ENSMUST00000135014; ENSMUSP00000119143; ENSMUSG00000057715. [Q8BZJ8-2]
DR Ensembl; ENSMUST00000141512; ENSMUSP00000139635; ENSMUSG00000057715. [Q8BZJ8-3]
DR Ensembl; ENSMUST00000171690; ENSMUSP00000132334; ENSMUSG00000057715. [Q8BZJ8-4]
DR GeneID; 320492; -.
DR KEGG; mmu:320492; -.
DR UCSC; uc007ahw.2; mouse. [Q8BZJ8-2]
DR UCSC; uc007ahx.2; mouse. [Q8BZJ8-1]
DR UCSC; uc007ahy.2; mouse. [Q8BZJ8-4]
DR UCSC; uc011wii.1; mouse. [Q8BZJ8-3]
DR MGI; MGI:2444149; A830018L16Rik.
DR VEuPathDB; HostDB:ENSMUSG00000057715; -.
DR eggNOG; ENOG502QUHG; Eukaryota.
DR GeneTree; ENSGT00390000005870; -.
DR HOGENOM; CLU_030572_0_0_1; -.
DR InParanoid; Q8BZJ8; -.
DR OrthoDB; 667565at2759; -.
DR PhylomeDB; Q8BZJ8; -.
DR BioGRID-ORCS; 320492; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8BZJ8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BZJ8; protein.
DR Bgee; ENSMUSG00000057715; Expressed in dentate gyrus of hippocampal formation granule cell and 50 other tissues.
DR ExpressionAtlas; Q8BZJ8; baseline and differential.
DR Genevisible; Q8BZJ8; MM.
DR InterPro; IPR040687; DUF5586.
DR PANTHER; PTHR32000; PTHR32000; 2.
DR Pfam; PF17824; DUF5586; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..459
FT /note="Uncharacterized protein C8orf34 homolog"
FT /id="PRO_0000330040"
FT REGION 66..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 227
FT /note="S -> R (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033016"
FT VAR_SEQ 228..459
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033017"
FT VAR_SEQ 283..287
FT /note="ENLDD -> GNFKN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033018"
FT VAR_SEQ 284..288
FT /note="NLDDL -> QIFSV (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033019"
FT VAR_SEQ 288..459
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033020"
FT VAR_SEQ 289..459
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033021"
SQ SEQUENCE 459 AA; 51086 MW; 42997A310FC93146 CRC64;
MASRQQTRIQ AYLEKNKIGP LFEELMTKLI TETPDQPIPF LIDHLQSKQG NQGQLQRALS
GSAALWAESE SSEPKGTRRD FRSYDKPWQM NAKKPKKSKS DLAVSNISPP SPDSKSLPRS
VDHLKWNWRT KPQSRDFDEL NHILQESKKL GKALENLSRS IAISDELDKE TLAFNSSLLR
PRVIGEWIGR AENDADPLAA EMLQPPVPRS KNDSWESEDS SSSPAGSLKM EPKTKGLKQQ
QQQHKKLLAA MLSQDSFESI HSPTPSVIEE DIDNEDDAME LLENLDDLRM EGVTTLVLSG
SKFNQGRPTH PAEPQAKVTL NICSRLQGDN LMERTEDTLQ ILHTPDEIIP DSLDSLPGTE
ETLMEEGEDF EKTSNLTEPG EASSGAHSLK SYMEEDESLK QLQVVHQPWL LPSDTESEGI
EAEQDKRSAD LLCVPCSSCP TLIYSGLSVK PAKEVASGP
