CH058_HUMAN
ID CH058_HUMAN Reviewed; 365 AA.
AC Q8NAV2; B4DI44;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Uncharacterized protein C8orf58;
GN Name=C8orf58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Corpus callosum, and Mesangial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NAV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NAV2-2; Sequence=VSP_024876;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR608004; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK092034; BAC03795.1; ALT_INIT; mRNA.
DR EMBL; AK295405; BAG58356.1; -; mRNA.
DR CCDS; CCDS34862.1; -. [Q8NAV2-1]
DR CCDS; CCDS56527.1; -. [Q8NAV2-2]
DR RefSeq; NP_001013864.1; NM_001013842.2. [Q8NAV2-1]
DR RefSeq; NP_775957.2; NM_173686.2. [Q8NAV2-2]
DR AlphaFoldDB; Q8NAV2; -.
DR BioGRID; 139076; 2.
DR IntAct; Q8NAV2; 2.
DR STRING; 9606.ENSP00000289989; -.
DR iPTMnet; Q8NAV2; -.
DR PhosphoSitePlus; Q8NAV2; -.
DR BioMuta; C8orf58; -.
DR DMDM; 146286069; -.
DR jPOST; Q8NAV2; -.
DR MaxQB; Q8NAV2; -.
DR PaxDb; Q8NAV2; -.
DR PeptideAtlas; Q8NAV2; -.
DR PRIDE; Q8NAV2; -.
DR ProteomicsDB; 72708; -. [Q8NAV2-1]
DR ProteomicsDB; 72709; -. [Q8NAV2-2]
DR Antibodypedia; 34991; 57 antibodies from 11 providers.
DR DNASU; 541565; -.
DR Ensembl; ENST00000289989.10; ENSP00000289989.5; ENSG00000241852.11. [Q8NAV2-1]
DR Ensembl; ENST00000409586.7; ENSP00000386265.3; ENSG00000241852.11. [Q8NAV2-2]
DR GeneID; 541565; -.
DR KEGG; hsa:541565; -.
DR MANE-Select; ENST00000289989.10; ENSP00000289989.5; NM_001013842.3; NP_001013864.1.
DR UCSC; uc003xce.4; human. [Q8NAV2-1]
DR CTD; 541565; -.
DR DisGeNET; 541565; -.
DR GeneCards; C8orf58; -.
DR HGNC; HGNC:32233; C8orf58.
DR HPA; ENSG00000241852; Low tissue specificity.
DR neXtProt; NX_Q8NAV2; -.
DR OpenTargets; ENSG00000241852; -.
DR PharmGKB; PA142672321; -.
DR VEuPathDB; HostDB:ENSG00000241852; -.
DR eggNOG; ENOG502RG07; Eukaryota.
DR GeneTree; ENSGT00390000000531; -.
DR HOGENOM; CLU_067480_0_0_1; -.
DR InParanoid; Q8NAV2; -.
DR OMA; IRWRSPK; -.
DR OrthoDB; 1384020at2759; -.
DR PhylomeDB; Q8NAV2; -.
DR TreeFam; TF337357; -.
DR PathwayCommons; Q8NAV2; -.
DR SignaLink; Q8NAV2; -.
DR BioGRID-ORCS; 541565; 14 hits in 1070 CRISPR screens.
DR ChiTaRS; C8orf58; human.
DR GenomeRNAi; 541565; -.
DR Pharos; Q8NAV2; Tdark.
DR PRO; PR:Q8NAV2; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8NAV2; protein.
DR Bgee; ENSG00000241852; Expressed in lower esophagus mucosa and 116 other tissues.
DR ExpressionAtlas; Q8NAV2; baseline and differential.
DR Genevisible; Q8NAV2; HS.
DR InterPro; IPR027958; DUF4657.
DR Pfam; PF15552; DUF4657; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..365
FT /note="Uncharacterized protein C8orf58"
FT /id="PRO_0000285640"
FT REGION 119..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..280
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 294..301
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024876"
FT CONFLICT 311
FT /note="R -> W (in Ref. 2; BAC03795)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 39661 MW; 63E4AF521AC22A8C CRC64;
MMGRRRAFAV DGRDGAGEGL ARGCIVPGVT STYRRIPDAA HGCSSWERGD KFRGVGREAL
FLKLASRDSG VEMAVGDSPL AALPGLSQDS LDFESSGSSE PPAQVGRLLA SQKLGEVLER
SRRLPTAPTS LSGQHRSLRL ASKPEREVPL GAGQQESMEA DTDLEAGLEE EAVGGLGPGA
WACLPGQGLR YLEHLCLVLE QMARLQQLYL QLRIQRPPGD PGEEESTRAP LPSPLHTPGN
RGQGPWELLS QTEHTGAKAA SPPKVEVPSA NPPRLPETPV EPTYHLPSSQ GHKRDISHWD
KVKVLLNRIC RRSHHHPEPP APPDGSDPRI ESRDLPERPQ CRPHRKTFMP SLVVKKQRAK
NLSVG
