CH058_MOUSE
ID CH058_MOUSE Reviewed; 365 AA.
AC Q66JV7; Q3V1T6; Q8K281;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Uncharacterized protein C8orf58 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66JV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66JV7-2; Sequence=VSP_024877;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32212.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK132259; BAE21063.1; -; mRNA.
DR EMBL; BC032212; AAH32212.1; ALT_INIT; mRNA.
DR EMBL; BC080738; AAH80738.1; -; mRNA.
DR CCDS; CCDS36967.1; -. [Q66JV7-2]
DR CCDS; CCDS49535.1; -. [Q66JV7-1]
DR RefSeq; NP_001004155.2; NM_001004155.2. [Q66JV7-2]
DR RefSeq; NP_001106206.1; NM_001112735.1. [Q66JV7-1]
DR AlphaFoldDB; Q66JV7; -.
DR PhosphoSitePlus; Q66JV7; -.
DR PaxDb; Q66JV7; -.
DR PRIDE; Q66JV7; -.
DR DNASU; 268759; -.
DR Ensembl; ENSMUST00000058240; ENSMUSP00000061834; ENSMUSG00000044551. [Q66JV7-2]
DR Ensembl; ENSMUST00000153871; ENSMUSP00000122309; ENSMUSG00000044551. [Q66JV7-1]
DR GeneID; 268759; -.
DR KEGG; mmu:268759; -.
DR UCSC; uc007ung.2; mouse. [Q66JV7-2]
DR UCSC; uc007unh.2; mouse. [Q66JV7-1]
DR MGI; MGI:2145726; 9930012K11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000044551; -.
DR eggNOG; ENOG502RG07; Eukaryota.
DR GeneTree; ENSGT00390000000531; -.
DR HOGENOM; CLU_067480_0_0_1; -.
DR InParanoid; Q66JV7; -.
DR OMA; IRWRSPK; -.
DR OrthoDB; 1384020at2759; -.
DR PhylomeDB; Q66JV7; -.
DR TreeFam; TF337357; -.
DR BioGRID-ORCS; 268759; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q66JV7; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q66JV7; protein.
DR Bgee; ENSMUSG00000044551; Expressed in placenta labyrinth and 143 other tissues.
DR ExpressionAtlas; Q66JV7; baseline and differential.
DR Genevisible; Q66JV7; MM.
DR InterPro; IPR027958; DUF4657.
DR Pfam; PF15552; DUF4657; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..365
FT /note="Uncharacterized protein C8orf58 homolog"
FT /id="PRO_0000285641"
FT REGION 218..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 295
FT /note="K -> KQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024877"
FT CONFLICT 91
FT /note="L -> R (in Ref. 2; AAH80738)"
FT /evidence="ECO:0000305"
FT CONFLICT 287..288
FT /note="IL -> VH (in Ref. 2; AAH80738)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 40582 MW; BE6805A3C3B50208 CRC64;
MLSRRRVFAV ERLGGRDGAF EDLAQGCVVP GVTCTYRRIP DNTHECSLDF REGQNELRGL
ERQMPLLKLA SQDSGMEMVV GDSSLATLSG LSQDSLNLEP MGSPELPPAQ LDRLLARQKL
EEVLERSREF PSLSAQRGPL QLLNKPVDGV PIFAGEQEST EADTELEAGL EEAKEVGNME
SAACTCLPGQ GLRYLEHLCL VLEQMVRLQQ LYLQLQTQRP SRDPEEEVLA PALSSSHIPD
NRVQEHREEL SQTKDPEGAE AASLPEVGVL VTSPSRLPEA LLEPTHILPP SQEPKDLSHW
DKVKVLLNRL RWRSPRLPEP PVPPDGSGSR MEFRNLSDRT PCHSQRKTFI PALVVKKPRA
KNLSV
