CH074_HUMAN
ID CH074_HUMAN Reviewed; 294 AA.
AC Q6P047; A2RUD6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein C8orf74;
GN Name=C8orf74;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PHE-15.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-15.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6P047; O60341: KDM1A; NbExp=2; IntAct=EBI-8466055, EBI-710124;
CC Q6P047; Q96LA8: PRMT6; NbExp=2; IntAct=EBI-8466055, EBI-912440;
CC Q6P047; O43463: SUV39H1; NbExp=2; IntAct=EBI-8466055, EBI-349968;
CC Q6P047; Q8N720: ZNF655; NbExp=3; IntAct=EBI-8466055, EBI-625509;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH65837.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC105001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471157; EAW65593.1; -; Genomic_DNA.
DR EMBL; BC065837; AAH65837.1; ALT_INIT; mRNA.
DR EMBL; BC132852; AAI32853.1; -; mRNA.
DR EMBL; BC132854; AAI32855.1; -; mRNA.
DR CCDS; CCDS47800.1; -.
DR RefSeq; NP_001035121.1; NM_001040032.1.
DR AlphaFoldDB; Q6P047; -.
DR SMR; Q6P047; -.
DR BioGRID; 128447; 12.
DR IntAct; Q6P047; 10.
DR MINT; Q6P047; -.
DR STRING; 9606.ENSP00000307129; -.
DR iPTMnet; Q6P047; -.
DR PhosphoSitePlus; Q6P047; -.
DR BioMuta; C8orf74; -.
DR DMDM; 296439406; -.
DR MassIVE; Q6P047; -.
DR PaxDb; Q6P047; -.
DR PeptideAtlas; Q6P047; -.
DR PRIDE; Q6P047; -.
DR ProteomicsDB; 66801; -.
DR Antibodypedia; 22088; 76 antibodies from 14 providers.
DR DNASU; 203076; -.
DR Ensembl; ENST00000304519.10; ENSP00000307129.5; ENSG00000171060.11.
DR GeneID; 203076; -.
DR KEGG; hsa:203076; -.
DR MANE-Select; ENST00000304519.10; ENSP00000307129.5; NM_001040032.2; NP_001035121.2.
DR UCSC; uc003wtd.1; human.
DR CTD; 203076; -.
DR DisGeNET; 203076; -.
DR GeneCards; C8orf74; -.
DR HGNC; HGNC:32296; C8orf74.
DR HPA; ENSG00000171060; Tissue enriched (testis).
DR neXtProt; NX_Q6P047; -.
DR OpenTargets; ENSG00000171060; -.
DR PharmGKB; PA142672337; -.
DR VEuPathDB; HostDB:ENSG00000171060; -.
DR eggNOG; ENOG502RYV3; Eukaryota.
DR GeneTree; ENSGT00940000154323; -.
DR HOGENOM; CLU_081156_0_0_1; -.
DR InParanoid; Q6P047; -.
DR OMA; FQFQRPQ; -.
DR OrthoDB; 1576738at2759; -.
DR PhylomeDB; Q6P047; -.
DR TreeFam; TF343725; -.
DR PathwayCommons; Q6P047; -.
DR SignaLink; Q6P047; -.
DR BioGRID-ORCS; 203076; 14 hits in 1057 CRISPR screens.
DR ChiTaRS; C8orf74; human.
DR GenomeRNAi; 203076; -.
DR Pharos; Q6P047; Tdark.
DR PRO; PR:Q6P047; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6P047; protein.
DR Bgee; ENSG00000171060; Expressed in left testis and 40 other tissues.
DR ExpressionAtlas; Q6P047; baseline and differential.
DR Genevisible; Q6P047; HS.
DR InterPro; IPR032727; CLAMP.
DR PANTHER; PTHR28457; PTHR28457; 1.
DR Pfam; PF14769; CLAMP; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..294
FT /note="Uncharacterized protein C8orf74"
FT /id="PRO_0000270931"
FT REGION 259..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 15
FT /note="L -> F (in dbSNP:rs11250058)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_033684"
FT VARIANT 222
FT /note="I -> V (in dbSNP:rs57041981)"
FT /id="VAR_061596"
SQ SEQUENCE 294 AA; 33735 MW; 555321ACEF4927C2 CRC64;
MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE SIIFAVGKGF
PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG HFNTTHLLAL CDYFHHTFIR
HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA
DVLLLKEALR LERENSLQKA FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ
IQNTFAILDL KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK
