ID   CH076_HUMAN             Reviewed;         380 AA.
AC   Q96K31; Q53HC1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Uncharacterized protein C8orf76;
GN   Name=C8orf76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Ovary;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Cerebellum;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=3;
CC         IsoId=Q96K31-1; Sequence=Displayed;
CC       Name=2; Synonyms=ZHX1-C8orf76;
CC         IsoId=Q96EF9-1; Sequence=External;
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DR   EMBL; AK027731; BAB55327.1; -; mRNA.
DR   EMBL; AK222660; BAD96380.1; -; mRNA.
DR   EMBL; AC068228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067796; AAH67796.1; -; mRNA.
DR   CCDS; CCDS6341.1; -. [Q96K31-1]
DR   RefSeq; NP_116236.1; NM_032847.2. [Q96K31-1]
DR   AlphaFoldDB; Q96K31; -.
DR   SMR; Q96K31; -.
DR   BioGRID; 124367; 18.
DR   STRING; 9606.ENSP00000276704; -.
DR   iPTMnet; Q96K31; -.
DR   PhosphoSitePlus; Q96K31; -.
DR   BioMuta; C8orf76; -.
DR   DMDM; 74732176; -.
DR   jPOST; Q96K31; -.
DR   MassIVE; Q96K31; -.
DR   MaxQB; Q96K31; -.
DR   PaxDb; Q96K31; -.
DR   PeptideAtlas; Q96K31; -.
DR   PRIDE; Q96K31; -.
DR   ProteomicsDB; 77037; -. [Q96K31-1]
DR   Antibodypedia; 13802; 73 antibodies from 13 providers.
DR   DNASU; 84933; -.
DR   Ensembl; ENST00000276704.6; ENSP00000276704.4; ENSG00000189376.12. [Q96K31-1]
DR   GeneID; 84933; -.
DR   KEGG; hsa:84933; -.
DR   MANE-Select; ENST00000276704.6; ENSP00000276704.4; NM_032847.3; NP_116236.1.
DR   UCSC; uc003yqc.3; human. [Q96K31-1]
DR   CTD; 84933; -.
DR   GeneCards; C8orf76; -.
DR   HGNC; HGNC:25924; C8orf76.
DR   HPA; ENSG00000189376; Low tissue specificity.
DR   neXtProt; NX_Q96K31; -.
DR   PharmGKB; PA142672339; -.
DR   VEuPathDB; HostDB:ENSG00000189376; -.
DR   eggNOG; ENOG502QW95; Eukaryota.
DR   GeneTree; ENSGT00390000011435; -.
DR   HOGENOM; CLU_044858_0_0_1; -.
DR   InParanoid; Q96K31; -.
DR   OMA; IKDEVHP; -.
DR   OrthoDB; 1578065at2759; -.
DR   PhylomeDB; Q96K31; -.
DR   TreeFam; TF332319; -.
DR   PathwayCommons; Q96K31; -.
DR   BioGRID-ORCS; 84933; 11 hits in 1047 CRISPR screens.
DR   GenomeRNAi; 84933; -.
DR   Pharos; Q96K31; Tdark.
DR   PRO; PR:Q96K31; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q96K31; protein.
DR   Bgee; ENSG00000189376; Expressed in lower esophagus mucosa and 102 other tissues.
DR   Genevisible; Q96K31; HS.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR041404; DUF5588.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR31919; PTHR31919; 1.
DR   Pfam; PF17826; DUF5588; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..380
FT                   /note="Uncharacterized protein C8orf76"
FT                   /id="PRO_0000225635"
FT   CONFLICT        373
FT                   /note="H -> R (in Ref. 2; BAD96380)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   380 AA;  43273 MW;  6965E80D3E3E8719 CRC64;
     MDSGCWLFGG EFEDSVFEER PERRSGPPAS YCAKLCEPQW FYEETESSDD VEVLTLKKFK
     GDLAYRRQEY QKALQEYSSI SEKLSSTNFA MKRDVQEGQA RCLAHLGRHM EALEIAANLE
     NKATNTDHLT TVLYLQLAIC SSLQNLEKTI FCLQKLISLH PFNPWNWGKL AEAYLNLGPA
     LSAALASSQK QHSFTSSDKT IKSFFPHSGK DCLLCFPETL PESSLFSVEA NSSNSQKNEK
     ALTNIQNCMA EKRETVLIET QLKACASFIR TRLLLQFTQP QQTSFALERN LRTQQEIEDK
     MKGFSFKEDT LLLIAEVMGE DIPEKIKDEV HPEVKCVGSV ALTALVTVSS EEFEDKWFRK
     IKDHFCPFEN QFHTEIQILA