ID   CH082_HUMAN             Reviewed;         216 AA.
AC   Q6P1X6; Q6GMR2; Q6P2Q7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=UPF0598 protein C8orf82;
GN   Name=C8orf82;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Ovary, Pancreas, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P1X6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P1X6-2; Sequence=VSP_034215;
CC   -!- SIMILARITY: Belongs to the UPF0598 family. {ECO:0000305}.
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DR   EMBL; CH471162; EAW82063.1; -; Genomic_DNA.
DR   EMBL; BC064373; AAH64373.1; -; mRNA.
DR   EMBL; BC064829; AAH64829.1; -; mRNA.
DR   EMBL; BC073936; AAH73936.1; -; mRNA.
DR   CCDS; CCDS34970.1; -. [Q6P1X6-1]
DR   RefSeq; NP_001001795.1; NM_001001795.1. [Q6P1X6-1]
DR   AlphaFoldDB; Q6P1X6; -.
DR   BioGRID; 136099; 165.
DR   IntAct; Q6P1X6; 6.
DR   STRING; 9606.ENSP00000436621; -.
DR   iPTMnet; Q6P1X6; -.
DR   PhosphoSitePlus; Q6P1X6; -.
DR   SwissPalm; Q6P1X6; -.
DR   BioMuta; C8orf82; -.
DR   DMDM; 190411564; -.
DR   EPD; Q6P1X6; -.
DR   jPOST; Q6P1X6; -.
DR   MassIVE; Q6P1X6; -.
DR   MaxQB; Q6P1X6; -.
DR   PaxDb; Q6P1X6; -.
DR   PeptideAtlas; Q6P1X6; -.
DR   PRIDE; Q6P1X6; -.
DR   ProteomicsDB; 66878; -. [Q6P1X6-1]
DR   ProteomicsDB; 66879; -. [Q6P1X6-2]
DR   Antibodypedia; 70565; 11 antibodies from 9 providers.
DR   DNASU; 414919; -.
DR   Ensembl; ENST00000524821.6; ENSP00000436621.1; ENSG00000213563.7. [Q6P1X6-1]
DR   Ensembl; ENST00000534680.5; ENSP00000434593.1; ENSG00000213563.7. [Q6P1X6-1]
DR   GeneID; 414919; -.
DR   KEGG; hsa:414919; -.
DR   MANE-Select; ENST00000524821.6; ENSP00000436621.1; NM_001001795.2; NP_001001795.1.
DR   UCSC; uc003zdp.2; human. [Q6P1X6-1]
DR   CTD; 414919; -.
DR   GeneCards; C8orf82; -.
DR   HGNC; HGNC:33826; C8orf82.
DR   HPA; ENSG00000213563; Low tissue specificity.
DR   neXtProt; NX_Q6P1X6; -.
DR   OpenTargets; ENSG00000213563; -.
DR   PharmGKB; PA162380827; -.
DR   VEuPathDB; HostDB:ENSG00000213563; -.
DR   eggNOG; ENOG502R8EE; Eukaryota.
DR   GeneTree; ENSGT00390000011521; -.
DR   HOGENOM; CLU_069446_2_0_1; -.
DR   InParanoid; Q6P1X6; -.
DR   OMA; YEPHKLY; -.
DR   OrthoDB; 1570646at2759; -.
DR   PhylomeDB; Q6P1X6; -.
DR   TreeFam; TF323959; -.
DR   PathwayCommons; Q6P1X6; -.
DR   SignaLink; Q6P1X6; -.
DR   BioGRID-ORCS; 414919; 12 hits in 1068 CRISPR screens.
DR   ChiTaRS; C8orf82; human.
DR   GenomeRNAi; 414919; -.
DR   Pharos; Q6P1X6; Tdark.
DR   PRO; PR:Q6P1X6; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q6P1X6; protein.
DR   Bgee; ENSG00000213563; Expressed in ileal mucosa and 148 other tissues.
DR   ExpressionAtlas; Q6P1X6; baseline and differential.
DR   Genevisible; Q6P1X6; HS.
DR   InterPro; IPR028108; DUF4505.
DR   PANTHER; PTHR31449; PTHR31449; 1.
DR   Pfam; PF14956; DUF4505; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..216
FT                   /note="UPF0598 protein C8orf82"
FT                   /id="PRO_0000340669"
FT   VAR_SEQ         1..68
FT                   /note="MWPPCGTLRTLALARSRGARACSGDGGVSYTQGQSPEPRTREYFYYVDHQGQ
FT                   LFLDDSKMKNFITCFK -> MGSPTLPTGPAHQGVGVLRSGAPLSEARRTSYRRRLPSV
FT                   WSWARRPWEPSALSTRTLHPP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_034215"
FT   CONFLICT        37
FT                   /note="E -> D (in Ref. 2; AAH64829)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   216 AA;  23889 MW;  79F2F20E81701640 CRC64;
     MWPPCGTLRT LALARSRGAR ACSGDGGVSY TQGQSPEPRT REYFYYVDHQ GQLFLDDSKM
     KNFITCFKDP QFLVTFFSRL RPNRSGRYEA AFPFLSPCGR ERNFLRCEDR PVVFTHLLTA
     DHGPPRLSYC GGGEALAVPF EPARLLPLAA NGRLYHPAPE RAGGVGLVRS ALAFELSACF
     EYGPGAPALP SHVRWQGRRL ALTMDLAPLL LAARSP