CH086_HUMAN
ID CH086_HUMAN Reviewed; 223 AA.
AC Q6ZUL3; A4QPB7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Uncharacterized protein C8orf86;
GN Name=C8orf86;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZUL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUL3-2; Sequence=VSP_035171, VSP_035172;
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DR EMBL; AK125570; BAC86207.1; -; mRNA.
DR EMBL; BC137511; AAI37512.1; -; mRNA.
DR EMBL; BC137512; AAI37513.1; -; mRNA.
DR EMBL; BC139744; AAI39745.1; -; mRNA.
DR RefSeq; NP_001290460.1; NM_001303531.1.
DR RefSeq; NP_997295.1; NM_207412.2.
DR AlphaFoldDB; Q6ZUL3; -.
DR BioGRID; 133205; 1.
DR STRING; 9606.ENSP00000350856; -.
DR iPTMnet; Q6ZUL3; -.
DR PhosphoSitePlus; Q6ZUL3; -.
DR BioMuta; C8orf86; -.
DR DMDM; 74712010; -.
DR PaxDb; Q6ZUL3; -.
DR PRIDE; Q6ZUL3; -.
DR DNASU; 389649; -.
DR GeneID; 389649; -.
DR UCSC; uc003xlx.1; human. [Q6ZUL3-1]
DR CTD; 389649; -.
DR GeneCards; C8orf86; -.
DR HGNC; HGNC:33774; C8orf86.
DR neXtProt; NX_Q6ZUL3; -.
DR PharmGKB; PA164717510; -.
DR eggNOG; ENOG502TFS7; Eukaryota.
DR HOGENOM; CLU_1239779_0_0_1; -.
DR InParanoid; Q6ZUL3; -.
DR OrthoDB; 1182188at2759; -.
DR PhylomeDB; Q6ZUL3; -.
DR TreeFam; TF353970; -.
DR PathwayCommons; Q6ZUL3; -.
DR BioGRID-ORCS; 389649; 13 hits in 1051 CRISPR screens.
DR GenomeRNAi; 389649; -.
DR Pharos; Q6ZUL3; Tdark.
DR PRO; PR:Q6ZUL3; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6ZUL3; protein.
DR InterPro; IPR040864; DUF5553.
DR Pfam; PF17707; DUF5553; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..223
FT /note="Uncharacterized protein C8orf86"
FT /id="PRO_0000348466"
FT REGION 40..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 106..140
FT /note="AYENTGHWERLASVVSSKTQQPTVISHSSISITFS -> PPQSSLLELWLLQ
FT RKHQNLRGTDWKCTFSSPAQNS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035171"
FT VAR_SEQ 141..223
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035172"
FT VARIANT 81
FT /note="R -> H (in dbSNP:rs1378332)"
FT /id="VAR_046186"
SQ SEQUENCE 223 AA; 24736 MW; AA7C536A70C7AD0A CRC64;
MRPLGKGLLP AEELIRSNLG VGRSLRDCLS QSGKLAEELG SKRLKPAKFG TEGKERVEQR
TERQRTGSSK EPRMQIICRR RWREPPPRLL WGCLMPRAQP LLHVTAYENT GHWERLASVV
SSKTQQPTVI SHSSISITFS HYPPATLDSF LVLEPIKLFP VSSLRSPLCL NCGSCRESIR
ISGELIGNAH SPAPPRTPEL ETLGWDKQAV LSGAQVILVC AEV
