ID   ACDH6_RHOJR             Reviewed;         299 AA.
AC   Q0RXC4; Q8KZT1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Acetaldehyde dehydrogenase 6 {ECO:0000255|HAMAP-Rule:MF_01657};
DE            EC=1.2.1.10 {ECO:0000255|HAMAP-Rule:MF_01657};
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating] 6 {ECO:0000255|HAMAP-Rule:MF_01657};
GN   Name=hpdG; OrderedLocusNames=RHA1_ro09018;
OS   Rhodococcus jostii (strain RHA1).
OG   Plasmid pRHL1.
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12514024; DOI=10.1128/aem.69.1.427-433.2003;
RA   Sakai M., Miyauchi K., Kato N., Masai E., Fukuda M.;
RT   "2-Hydroxypenta-2,4-dienoate metabolic pathway genes in a strong
RT   polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1.";
RL   Appl. Environ. Microbiol. 69:427-433(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH;
CC         Xref=Rhea:RHEA:23288, ChEBI:CHEBI:15343, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.10; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01657};
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABH00062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB085906; BAB97164.1; -; Genomic_DNA.
DR   EMBL; CP000432; ABH00062.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041813279.1; NC_008269.1.
DR   AlphaFoldDB; Q0RXC4; -.
DR   SMR; Q0RXC4; -.
DR   EnsemblBacteria; ABH00062; ABH00062; RHA1_ro09018.
DR   KEGG; rha:RHA1_ro09018; -.
DR   PATRIC; fig|101510.16.peg.8301; -.
DR   HOGENOM; CLU_062208_0_0_11; -.
DR   Proteomes; UP000008710; Plasmid pRHL1.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01657; Ac_ald_DH_ac; 1.
DR   InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR   InterPro; IPR015426; Acetylaldehyde_DH_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..299
FT                   /note="Acetaldehyde dehydrogenase 6"
FT                   /id="PRO_0000387731"
FT   ACT_SITE        125
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT   BINDING         156..164
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT   BINDING         275
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
SQ   SEQUENCE   299 AA;  31708 MW;  E0F9484669CC9144 CRC64;
     MEPINAAIVG PGNIGTDLLA KLERVDSIAV QYVVGVVESD GLERARAKGI SASAGGVDWL
     LEQDPLPEIV FEATSAKAHQ LNAPRYHELN IQAVDLTPAH IGPMVCPPVN LTHHIDAPNV
     SMITCGGQAT IPMVHAVSRV SAVPYAEIVA SVASRGAGPG TRANIDEFTQ TTGQAVSEVG
     GAARGRAIII LNPMEPPMIM RDTVYCMIDA DADRDAISES VHRMVTEVQA YVPGYRLRAD
     PQFDDPKDGW DGHGRVAIFL EVEGNGDYLP KYAGNLDIMT AAAARVGDSI ARNRMGVPA