ID   CH15_DROME              Reviewed;         115 AA.
AC   P07185; A4ULV6; A8E796; Q9VSP2;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Chorion protein S15;
DE   Flags: Precursor;
GN   Name=Cp15; Synonyms=s15; ORFNames=CG6519;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2988878; DOI=10.1007/bf00328464;
RA   Wong Y.-C., Pustell J., Spoerel N., Kafatos F.C.;
RT   "Coding and potential regulatory sequences of a cluster of chorion genes in
RT   Drosophila melanogaster.";
RL   Chromosoma 92:124-135(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Canton-S;
RX   PubMed=3924529; DOI=10.1007/bf00328465;
RA   Levine J., Spradling A.;
RT   "DNA sequence of a 3.8 kilobase pair region controlling Drosophila chorion
RT   gene amplification.";
RL   Chromosoma 92:136-142(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17244601; DOI=10.1093/molbev/msm009;
RA   Jagadeeshan S., Singh R.S.;
RT   "Rapid evolution of outer egg membrane proteins in the Drosophila
RT   melanogaster subgroup: a case of ecologically driven evolution of female
RT   reproductive traits.";
RL   Mol. Biol. Evol. 24:929-938(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC       protecting the egg from the environment.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the chorion protein S15/S18 family.
CC       {ECO:0000305}.
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DR   EMBL; X02497; CAA26329.1; -; Genomic_DNA.
DR   EMBL; X06257; CAA29603.1; -; Genomic_DNA.
DR   EMBL; EF441624; ABO71665.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAF50374.1; -; Genomic_DNA.
DR   EMBL; BT031038; ABV82420.1; -; mRNA.
DR   RefSeq; NP_523979.1; NM_079255.2.
DR   AlphaFoldDB; P07185; -.
DR   BioGRID; 64405; 13.
DR   DIP; DIP-18313N; -.
DR   STRING; 7227.FBpp0076299; -.
DR   PaxDb; P07185; -.
DR   DNASU; 38999; -.
DR   EnsemblMetazoa; FBtr0076572; FBpp0076299; FBgn0000355.
DR   GeneID; 38999; -.
DR   KEGG; dme:Dmel_CG6519; -.
DR   CTD; 38999; -.
DR   FlyBase; FBgn0000355; Cp15.
DR   VEuPathDB; VectorBase:FBgn0000355; -.
DR   eggNOG; ENOG502TBSK; Eukaryota.
DR   HOGENOM; CLU_2075586_0_0_1; -.
DR   InParanoid; P07185; -.
DR   OMA; CINANPY; -.
DR   OrthoDB; 1630300at2759; -.
DR   PhylomeDB; P07185; -.
DR   BioGRID-ORCS; 38999; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 38999; -.
DR   PRO; PR:P07185; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0000355; Expressed in secondary oocyte and 12 other tissues.
DR   Genevisible; P07185; DM.
DR   GO; GO:0042600; C:egg chorion; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005649; Chorion_2.
DR   Pfam; PF03964; Chorion_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..115
FT                   /note="Chorion protein S15"
FT                   /id="PRO_0000089613"
SQ   SEQUENCE   115 AA;  11981 MW;  4E386EB446DE30A1 CRC64;
     MKYLIVCVTL ALFAYINASP AYGNRGGYGG GYGGGYGPVQ RVVYEEVPAY GPSRGYNSYP
     RSLRSEGNGG SAAAAAAASA AAVNPGTYKQ YAIPSYELDG ARGYEIGHGY GQRAY