CH16_DROME
ID CH16_DROME Reviewed; 138 AA.
AC P22977; A4UM28; A8E6S3; A8E6T0; A8E6U5; Q3YMV2; Q9VSP4;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Chorion protein S16;
DE Flags: Precursor;
GN Name=Cp16; Synonyms=s16; ORFNames=CG6533;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP VARIANTS HIS-24; TYR-70 AND ALA-71.
RX PubMed=2509714; DOI=10.1007/bf02100110;
RA Fenerjian M.G., Martinez-Cruzado J.C., Swimmer C., King D., Kafatos F.C.;
RT "Evolution of the autosomal chorion cluster in Drosophila. II. Chorion gene
RT expression and sequence comparisons of the s16 and s19 genes in
RT evolutionarily distant species.";
RL J. Mol. Evol. 29:108-125(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Ovary;
RX PubMed=15917496; DOI=10.1093/molbev/msi175;
RA Jagadeeshan S., Singh R.S.;
RT "Rapidly evolving genes of Drosophila: differing levels of selective
RT pressure in testis, ovary, and head tissues between sibling species.";
RL Mol. Biol. Evol. 22:1793-1801(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-24; TYR-70 AND ALA-71.
RC STRAIN=0231.01, Kronenbourg, Madibou4, Primus20, Primus25, ZH34, and ZH83;
RX PubMed=17244601; DOI=10.1093/molbev/msm009;
RA Jagadeeshan S., Singh R.S.;
RT "Rapid evolution of outer egg membrane proteins in the Drosophila
RT melanogaster subgroup: a case of ecologically driven evolution of female
RT reproductive traits.";
RL Mol. Biol. Evol. 24:929-938(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC protecting the egg from the environment. {ECO:0000269|PubMed:2509714}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2509714}.
CC -!- SIMILARITY: Belongs to the chorion protein S16 family. {ECO:0000305}.
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DR EMBL; X16715; CAA34686.1; -; Genomic_DNA.
DR EMBL; DQ062774; AAY56647.1; -; mRNA.
DR EMBL; EF441633; ABO71674.1; -; Genomic_DNA.
DR EMBL; EF441696; ABO71737.1; -; Genomic_DNA.
DR EMBL; EF441697; ABO71738.1; -; Genomic_DNA.
DR EMBL; EF441698; ABO71739.1; -; Genomic_DNA.
DR EMBL; EF441699; ABO71740.1; -; Genomic_DNA.
DR EMBL; EF441700; ABO71741.1; -; Genomic_DNA.
DR EMBL; EF441701; ABO71742.1; -; Genomic_DNA.
DR EMBL; EF441702; ABO71743.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50372.1; -; Genomic_DNA.
DR EMBL; BT030865; ABV82247.1; -; mRNA.
DR EMBL; BT030872; ABV82254.1; -; mRNA.
DR EMBL; BT030887; ABV82269.1; -; mRNA.
DR EMBL; BT030893; ABV82275.1; -; mRNA.
DR PIR; A32998; A32998.
DR RefSeq; NP_523981.1; NM_079257.3.
DR AlphaFoldDB; P22977; -.
DR BioGRID; 64407; 4.
DR IntAct; P22977; 2.
DR STRING; 7227.FBpp0076301; -.
DR PaxDb; P22977; -.
DR PRIDE; P22977; -.
DR DNASU; 39001; -.
DR EnsemblMetazoa; FBtr0076574; FBpp0076301; FBgn0000356.
DR GeneID; 39001; -.
DR KEGG; dme:Dmel_CG6533; -.
DR CTD; 39001; -.
DR FlyBase; FBgn0000356; Cp16.
DR VEuPathDB; VectorBase:FBgn0000356; -.
DR eggNOG; ENOG502T818; Eukaryota.
DR HOGENOM; CLU_153425_0_0_1; -.
DR InParanoid; P22977; -.
DR OMA; NRYGWEQ; -.
DR OrthoDB; 1521384at2759; -.
DR PhylomeDB; P22977; -.
DR BioGRID-ORCS; 39001; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Cp16; fly.
DR GenomeRNAi; 39001; -.
DR PRO; PR:P22977; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000356; Expressed in secondary oocyte and 5 other tissues.
DR ExpressionAtlas; P22977; baseline and differential.
DR Genevisible; P22977; DM.
DR GO; GO:0042600; C:egg chorion; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
DR InterPro; IPR008450; Chorion_S16.
DR Pfam; PF05836; Chorion_S16; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..138
FT /note="Chorion protein S16"
FT /id="PRO_0000089617"
FT VARIANT 24
FT /note="N -> H (in strain: Kronenbourg, Madibou4, Primus20,
FT Primus25, ZH34 and ZH83)"
FT /evidence="ECO:0000269|PubMed:17244601,
FT ECO:0000269|PubMed:2509714"
FT VARIANT 70
FT /note="N -> Y (in strain: Kronenbourg, Madibou4, Primus20,
FT Primus25, ZH34 and ZH83)"
FT /evidence="ECO:0000269|PubMed:17244601,
FT ECO:0000269|PubMed:2509714"
FT VARIANT 71
FT /note="S -> A (in strain: Kronenbourg, Madibou4, Primus20,
FT Primus25, ZH34 and ZH83)"
FT /evidence="ECO:0000269|PubMed:17244601,
FT ECO:0000269|PubMed:2509714"
FT CONFLICT 35
FT /note="Missing (in Ref. 6; ABV82254)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="A -> V (in Ref. 6; ABV82269)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 138 AA; 14265 MW; DED024340A5209D7 CRC64;
MSATLRLLCL MACCVALAVA NRPNYGGSGY GASYGDVVKA AETAEAQASA LTNAAGAAAS
AAKLDGADWN SLNRYGWEQG RPLLAKPYGP LDPLYAAALP PRSFVAEVDP VFKKSQYGGS
YGENAYLKTD AKLGVVAI
