ID   CH18_DROGR              Reviewed;         166 AA.
AC   P24513; B4IWK8;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Chorion protein S18;
DE   Flags: Precursor;
GN   Name=Cp18; Synonyms=S18; ORFNames=GH15323;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2213881; DOI=10.1016/s0022-2836(05)80341-9;
RA   Swimmer C., Fenerjian M.G., Martinez-Cruzado J.C., Kafatos F.C.;
RT   "Evolution of the autosomal chorion cluster in Drosophila. III. Comparison
RT   of the s18 gene in evolutionarily distant species and heterospecific
RT   control of chorion gene amplification.";
RL   J. Mol. Biol. 215:225-235(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC       protecting the egg from the environment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chorion protein S15/S18 family.
CC       {ECO:0000305}.
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DR   EMBL; X53422; CAA37504.1; -; Genomic_DNA.
DR   EMBL; CH916366; EDV96234.1; -; Genomic_DNA.
DR   PIR; S13219; S13219.
DR   RefSeq; XP_001983886.1; XM_001983850.1.
DR   AlphaFoldDB; P24513; -.
DR   STRING; 7222.FBpp0149229; -.
DR   EnsemblMetazoa; FBtr0150737; FBpp0149229; FBgn0012319.
DR   GeneID; 6557096; -.
DR   KEGG; dgr:6557096; -.
DR   eggNOG; ENOG502TBAZ; Eukaryota.
DR   HOGENOM; CLU_1541752_0_0_1; -.
DR   InParanoid; P24513; -.
DR   OMA; FMCIFVC; -.
DR   OrthoDB; 1641609at2759; -.
DR   PhylomeDB; P24513; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0042600; C:egg chorion; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005649; Chorion_2.
DR   Pfam; PF03964; Chorion_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..166
FT                   /note="Chorion protein S18"
FT                   /id="PRO_0000089620"
SQ   SEQUENCE   166 AA;  16810 MW;  A710BEEBE14F56FE CRC64;
     MMKFMCLFVC AIAAVSASDY GNVGYGRVPV GGLAYQVQPA LTVSSIVPVG GYGGGYGGGR
     GYGRGYGRSV EVPVAAVWTP NSRYGVAPVD RQALGLAKLS LAAPGAGGPL VLNEPRRIIK
     VSGYGPQRGY KQPLGYGSIE QAQGASAAAA SSSVAGQNKG YQNGGY