CH18_DROME
ID CH18_DROME Reviewed; 172 AA.
AC P07184; A4ULX3; A8E6T8; Q9VSP1;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Chorion protein S18;
DE Flags: Precursor;
GN Name=Cp18; Synonyms=s18; ORFNames=CG6517;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2988878; DOI=10.1007/bf00328464;
RA Wong Y.-C., Pustell J., Spoerel N., Kafatos F.C.;
RT "Coding and potential regulatory sequences of a cluster of chorion genes in
RT Drosophila melanogaster.";
RL Chromosoma 92:124-135(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=3924529; DOI=10.1007/bf00328465;
RA Levine J., Spradling A.;
RT "DNA sequence of a 3.8 kilobase pair region controlling Drosophila chorion
RT gene amplification.";
RL Chromosoma 92:136-142(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17244601; DOI=10.1093/molbev/msm009;
RA Jagadeeshan S., Singh R.S.;
RT "Rapid evolution of outer egg membrane proteins in the Drosophila
RT melanogaster subgroup: a case of ecologically driven evolution of female
RT reproductive traits.";
RL Mol. Biol. Evol. 24:929-938(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC protecting the egg from the environment.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the chorion protein S15/S18 family.
CC {ECO:0000305}.
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DR EMBL; X02497; CAA26328.1; -; Genomic_DNA.
DR EMBL; X06257; CAA29602.1; -; Genomic_DNA.
DR EMBL; EF441641; ABO71682.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50375.1; -; Genomic_DNA.
DR EMBL; BT030880; ABV82262.1; -; mRNA.
DR EMBL; BT030881; ABV82263.1; -; mRNA.
DR EMBL; BT030884; ABV82266.1; -; mRNA.
DR EMBL; BT030898; ABV82280.1; -; mRNA.
DR EMBL; BT031212; ABY20453.1; -; mRNA.
DR EMBL; BT031216; ABY20457.1; -; mRNA.
DR EMBL; BT031218; ABY20459.1; -; mRNA.
DR EMBL; BT031221; ABY20462.1; -; mRNA.
DR EMBL; BT031229; ABY20470.1; -; mRNA.
DR RefSeq; NP_523978.1; NM_079254.2.
DR AlphaFoldDB; P07184; -.
DR BioGRID; 64404; 2.
DR IntAct; P07184; 1.
DR STRING; 7227.FBpp0076298; -.
DR PaxDb; P07184; -.
DR DNASU; 38998; -.
DR EnsemblMetazoa; FBtr0076571; FBpp0076298; FBgn0000357.
DR GeneID; 38998; -.
DR KEGG; dme:Dmel_CG6517; -.
DR CTD; 38998; -.
DR FlyBase; FBgn0000357; Cp18.
DR VEuPathDB; VectorBase:FBgn0000357; -.
DR eggNOG; ENOG502TBAZ; Eukaryota.
DR HOGENOM; CLU_1541752_0_0_1; -.
DR InParanoid; P07184; -.
DR OMA; FMCIFVC; -.
DR PhylomeDB; P07184; -.
DR SignaLink; P07184; -.
DR BioGRID-ORCS; 38998; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38998; -.
DR PRO; PR:P07184; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000357; Expressed in secondary oocyte and 11 other tissues.
DR ExpressionAtlas; P07184; baseline and differential.
DR Genevisible; P07184; DM.
DR GO; GO:0042600; C:egg chorion; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005213; F:structural constituent of egg chorion; TAS:FlyBase.
DR InterPro; IPR005649; Chorion_2.
DR Pfam; PF03964; Chorion_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..172
FT /note="Chorion protein S18"
FT /id="PRO_0000089621"
FT CONFLICT 23
FT /note="S -> P (in Ref. 1; CAA26328 and 2; CAA29602)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="A -> V (in Ref. 1; CAA26328 and 2; CAA29602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 17231 MW; 9CB9E53E7DAC9D79 CRC64;
MMKFMCICLC AISAVSANSY GRSRGGYGGA PVGGYAYQVQ PALTVKAIVP SYGGGYGGNH
GGYGGAYESV PVPVSSAYSG ANVGSQYSGS GYGGAPPVDA QAIALAKLAL AAPSAGAPLV
WKEAPRYAQP VYPPTSYVNQ EYGHSEKVKG GSAAAAASSV AAGKKGYKRP SY
