ID   CH19_DROME              Reviewed;         173 AA.
AC   P07186; A8E6S9; A8E6T1; A8E7A0; Q9VSP3;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Chorion protein S19;
DE   Flags: Precursor;
GN   Name=Cp19; Synonyms=s19; ORFNames=CG6524;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2988878; DOI=10.1007/bf00328464;
RA   Wong Y.-C., Pustell J., Spoerel N., Kafatos F.C.;
RT   "Coding and potential regulatory sequences of a cluster of chorion genes in
RT   Drosophila melanogaster.";
RL   Chromosoma 92:124-135(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC       protecting the egg from the environment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chorion protein S19 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABV82253.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X02497; CAA26330.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAF50373.1; -; Genomic_DNA.
DR   EMBL; BT030871; ABV82253.1; ALT_FRAME; mRNA.
DR   EMBL; BT030873; ABV82255.1; -; mRNA.
DR   EMBL; BT030885; ABV82267.1; -; mRNA.
DR   EMBL; BT030886; ABV82268.1; -; mRNA.
DR   EMBL; BT031042; ABV82424.1; -; mRNA.
DR   RefSeq; NP_523980.1; NM_079256.4.
DR   AlphaFoldDB; P07186; -.
DR   DIP; DIP-17693N; -.
DR   IntAct; P07186; 1.
DR   STRING; 7227.FBpp0076300; -.
DR   PaxDb; P07186; -.
DR   PRIDE; P07186; -.
DR   DNASU; 39000; -.
DR   EnsemblMetazoa; FBtr0076573; FBpp0076300; FBgn0000358.
DR   GeneID; 39000; -.
DR   KEGG; dme:Dmel_CG6524; -.
DR   CTD; 39000; -.
DR   FlyBase; FBgn0000358; Cp19.
DR   VEuPathDB; VectorBase:FBgn0000358; -.
DR   eggNOG; ENOG502S3GF; Eukaryota.
DR   HOGENOM; CLU_1410206_0_0_1; -.
DR   InParanoid; P07186; -.
DR   OMA; PEYSKVI; -.
DR   OrthoDB; 1521706at2759; -.
DR   PhylomeDB; P07186; -.
DR   SignaLink; P07186; -.
DR   BioGRID-ORCS; 39000; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39000; -.
DR   PRO; PR:P07186; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0000358; Expressed in secondary oocyte and 6 other tissues.
DR   Genevisible; P07186; DM.
DR   GO; GO:0042600; C:egg chorion; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005649; Chorion_2.
DR   InterPro; IPR009611; S19_C.
DR   Pfam; PF03964; Chorion_2; 1.
DR   Pfam; PF06756; S19; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..173
FT                   /note="Chorion protein S19"
FT                   /id="PRO_0000089625"
FT   CONFLICT        15
FT                   /note="I -> V (in Ref. 4; ABV82424)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   173 AA;  18525 MW;  209D7BDCBE27569A CRC64;
     MNKFATLAVI FCACIVGSCY ANYGGQQSYG QRSYGQDSSA ASAASSAAAA GAEGQQRYER
     PVEIIAGGYR GSYAPEILRP IQVSGGYGGE RRGYNGGNYR RAGYGPRWTV QPAGATLLYP
     GQNNYKAYVS PPEYSKVILP IRPAAPVAKL FVPENQYGNQ YVSQYSAPRS SGY