ID   CH2BB_XENLA             Reviewed;         214 AA.
AC   Q66IV6;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Charged multivesicular body protein 2b-B;
DE   AltName: Full=Chromatin-modifying protein 2b-B;
DE            Short=CHMP2b-B;
GN   Name=chmp2b-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Late endosome
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC081171; AAH81171.1; -; mRNA.
DR   RefSeq; NP_001087752.1; NM_001094283.1.
DR   AlphaFoldDB; Q66IV6; -.
DR   SMR; Q66IV6; -.
DR   BioGRID; 104436; 1.
DR   IntAct; Q66IV6; 1.
DR   MaxQB; Q66IV6; -.
DR   PRIDE; Q66IV6; -.
DR   DNASU; 447576; -.
DR   GeneID; 447576; -.
DR   KEGG; xla:447576; -.
DR   CTD; 447576; -.
DR   Xenbase; XB-GENE-948825; chmp2b.L.
DR   OMA; NMREFQM; -.
DR   OrthoDB; 1480977at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447576; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..214
FT                   /note="Charged multivesicular body protein 2b-B"
FT                   /id="PRO_0000211475"
FT   REGION          178..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..55
FT                   /evidence="ECO:0000255"
FT   MOTIF           202..212
FT                   /note="MIT-interacting motif"
SQ   SEQUENCE   214 AA;  23949 MW;  C2A6E260186A4946 CRC64;
     MASLFKKKTV DDIIREQNKE LRGTQRAITR DRAALEKQEK QLEMEIKKMA KTGNKDACRV
     LAKQLVQLRK QKTRTYAVSS KVTSMSTQTK VMSSQMKMAG AMSTTAKTMQ AVNKKMDPQK
     TLQTMQNFQK ENMKMEMTDE MINDTLDDIF DASEDEEESQ DIVNQVLDEI GIEISGKMAK
     APSAAKGLPS TSAAKSKGIS DEEIERQLKA LGVD