ACDH_NOVAR
ID ACDH_NOVAR Reviewed; 312 AA.
AC O85978;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Acetaldehyde dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01657};
DE EC=1.2.1.10 {ECO:0000255|HAMAP-Rule:MF_01657};
DE AltName: Full=Acetaldehyde dehydrogenase [acetylating] {ECO:0000255|HAMAP-Rule:MF_01657};
GN Name=xylQ;
OS Novosphingobium aromaticivorans (Sphingomonas aromaticivorans).
OG Plasmid pNL1.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=48935;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 700278 / DSM 12444 / F199;
RX PubMed=10049392; DOI=10.1128/jb.181.5.1585-1602.1999;
RA Romine M.F., Stillwell L.C., Wong K.-K., Thurston S.J., Sisk E.C.,
RA Sensen C., Gaasterland T., Fredrickson J.K., Saffer J.D.;
RT "Complete sequence of a 184-kilobase catabolic plasmid from Sphingomonas
RT aromaticivorans F199.";
RL J. Bacteriol. 181:1585-1602(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH;
CC Xref=Rhea:RHEA:23288, ChEBI:CHEBI:15343, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.10; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01657};
CC -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
CC {ECO:0000255|HAMAP-Rule:MF_01657}.
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DR EMBL; AF079317; AAD03994.1; -; Genomic_DNA.
DR PIR; T31270; T31270.
DR RefSeq; NP_049198.1; NC_002033.1.
DR RefSeq; WP_010891016.1; NC_002033.1.
DR AlphaFoldDB; O85978; -.
DR SMR; O85978; -.
DR OMA; TSAYVHK; -.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01657; Ac_ald_DH_ac; 1.
DR InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR InterPro; IPR015426; Acetylaldehyde_DH_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR Pfam; PF09290; AcetDehyd-dimer; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE 3: Inferred from homology;
KW Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT CHAIN 1..312
FT /note="Acetaldehyde dehydrogenase"
FT /id="PRO_0000387742"
FT ACT_SITE 129
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT BINDING 11..14
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT BINDING 160..168
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
FT BINDING 287
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01657"
SQ SEQUENCE 312 AA; 32847 MW; 5E4C8274051EA8CF CRC64;
MAKMKCAIIG SGNIGTDLMI KLLKGSDTLE LAAVVGIDPA SEGLAMASER GVPTTHEGIE
GLCRMPQYAD IGIAFDATSA YAHKAHDEIL ARDGKLMVDL TPAAIGPATI PPVNPAVDAA
VRNINMVTCG GQATIPIVAA VSQVAKVHYA EIVASVSSRS AGPGTRANID EFTRTTARAI
ETVGGAAKGR AVIILNPAEP PMIMRDTIFT LSEMVDEDKV RDSVLAMIAR VQSYVPGYRL
KQEVQFERFG SNRPLKIPGY GEFEGLKTSV FLEVEGAGDY LPNYSGNLDI MTAAAKAAGE
SLAKTHMEKT AA
