ID   ACDP_MYCLE              Reviewed;         389 AA.
AC   P46703;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable acyl-CoA dehydrogenase fadE25;
DE            EC=1.3.99.-;
GN   Name=fadE25; Synonyms=acd; OrderedLocusNames=ML0737; ORFNames=B1308_F1_34;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7489918; DOI=10.1016/0378-1119(95)00427-8;
RA   Doukhan L., Predich M., Nair G., Dussurget O., Mandic-Mulec I., Cole S.T.,
RA   Smith D.R., Smith I.;
RT   "Genomic organization of the mycobacterial sigma gene cluster.";
RL   Gene 165:67-70(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2;
CC         Xref=Rhea:RHEA:48608, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:60015, ChEBI:CHEBI:65111;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; U00012; AAA85936.1; -; Genomic_DNA.
DR   EMBL; AL583919; CAC30246.1; -; Genomic_DNA.
DR   PIR; B87001; B87001.
DR   RefSeq; NP_301577.1; NC_002677.1.
DR   RefSeq; WP_010907901.1; NC_002677.1.
DR   AlphaFoldDB; P46703; -.
DR   SMR; P46703; -.
DR   STRING; 272631.ML0737; -.
DR   PRIDE; P46703; -.
DR   EnsemblBacteria; CAC30246; CAC30246; CAC30246.
DR   KEGG; mle:ML0737; -.
DR   PATRIC; fig|272631.5.peg.1334; -.
DR   Leproma; ML0737; -.
DR   eggNOG; COG1960; Bacteria.
DR   HOGENOM; CLU_018204_0_2_11; -.
DR   OMA; NMATWML; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Gene3D; 1.10.540.10; -; 1.
DR   Gene3D; 2.40.110.10; -; 1.
DR   InterPro; IPR006089; Acyl-CoA_DH_CS.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR   SUPFAM; SSF47203; SSF47203; 1.
DR   SUPFAM; SSF56645; SSF56645; 1.
DR   PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR   PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Probable acyl-CoA dehydrogenase fadE25"
FT                   /id="PRO_0000201187"
SQ   SEQUENCE   389 AA;  41719 MW;  EFC80CDB3ED884B1 CRC64;
     MVGWSGNPLF DLFKLPEEHN ELRATIRALA EKEIAPHAAD VDQRARFPEE ALAALNASGF
     NAIHVPEEYG GQGADSVAAC IVIEEVARVD ASASLIPAVN KLGTMGLILR GSEELKKQVL
     PSLAAEGAMA SYALSEREAG SDAASMRTRA KADGDDWILN GFKCWITNGG KSTWYTVMAV
     TDPDKGANGI SAFIVHKDDE GFSIGPKEKK LGIKGSPTTE LYFDKCRIPG DRIIGEPGTG
     FKTALATLDH TRPTIGAQAV GIAQGALDAA IVYTKDRKQF GESISTFQSI QFMLADMAMK
     VEAARLIVYA AAARAERGEP DLGFISAASK CFASDIAMEV TTDAVQLFGG AGYTSDFPVE
     RFMRDAKITQ IYEGTNQIQR VVMSRALLR