ID   ACE2_HYPJE              Reviewed;         341 AA.
AC   Q96WN6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Transcription factor ACEII;
GN   Name=ace2 {ECO:0000312|EMBL:AAK69383.1};
OS   Hypocrea jecorina (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=51453;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK69383.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 26921 / CBS 392.92 / QM9414;
RX   PubMed=11304525; DOI=10.1074/jbc.m003624200;
RA   Aro N., Saloheimo A., Ilmen M., Penttilae M.;
RT   "ACEII, a novel transcriptional activator involved in regulation of
RT   cellulase and xylanase genes of Trichoderma reesei.";
RL   J. Biol. Chem. 276:24309-24314(2001).
CC   -!- FUNCTION: Positive regulation of the major cellulase and xylanase genes
CC       (cbh1, cbh2, egl2 and xyn2). Binds to the 5'-GGCTAATAA-3' site present
CC       in the cbh1 promoter. {ECO:0000269|PubMed:11304525}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AF220671; AAK69383.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q96WN6; -.
DR   SMR; Q96WN6; -.
DR   VEuPathDB; FungiDB:TrQ_002332; -.
DR   OMA; VMACHIR; -.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..341
FT                   /note="Transcription factor ACEII"
FT                   /id="PRO_0000114929"
FT   DNA_BIND        7..36
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   341 AA;  37725 MW;  190F68D4571F92F5 CRC64;
     MDLRQACDRC HDKKLRCPRI SGSPCCSRCA KANVACVFSP PSRPFRPHEP LNHSHEHSHS
     HSHNHNGVGV SFDWLDLMSL EQQQEQQQGQ PQHPPPPVQT LSERLAALLC ALDRMLQAVP
     SSLDMHHVSR QQLREYADTV GTGFDLQSTL DSLLHHAQDL ASLYSEAVPA SFNKRTTAAE
     ADALCAVPDC VHQDRTSLHT TPLPKLDHAL LNLVMACHIR LLDVMDTLAE HGRMCAFMVA
     TLPPDYDPKF AVPEIRVGTF VAPTDTAASM LLSVVVELQT VLVARVKDLV AMVDQVKDDA
     RAAREAKVVR LQCGILLERA ESTLGEWSRF KDGLVSARLL K