ACE2_SCHPO
ID ACE2_SCHPO Reviewed; 533 AA.
AC O14258;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Metallothionein expression activator;
GN Name=ace2; ORFNames=SPAC6G10.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=12665550; DOI=10.1242/jcs.00377;
RA Martin-Cuadrado A.B., Duenas E., Sipiczki M., de Aldana C.R.V., del Rey F.;
RT "The endo-beta-1,3-glucanase eng1p is required for dissolution of the
RT primary septum during cell separation in Schizosaccharomyces pombe.";
RL J. Cell Sci. 116:1689-1698(2003).
CC -!- FUNCTION: Regulates the transcription of genes required for cell
CC separation. {ECO:0000269|PubMed:12665550}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CU329670; CAB11298.1; -; Genomic_DNA.
DR PIR; T39062; T39062.
DR RefSeq; NP_594109.1; NM_001019533.2.
DR AlphaFoldDB; O14258; -.
DR SMR; O14258; -.
DR BioGRID; 278157; 134.
DR IntAct; O14258; 1.
DR MINT; O14258; -.
DR STRING; 4896.SPAC6G10.12c.1; -.
DR iPTMnet; O14258; -.
DR PaxDb; O14258; -.
DR PRIDE; O14258; -.
DR EnsemblFungi; SPAC6G10.12c.1; SPAC6G10.12c.1:pep; SPAC6G10.12c.
DR GeneID; 2541661; -.
DR KEGG; spo:SPAC6G10.12c; -.
DR PomBase; SPAC6G10.12c; ace2.
DR VEuPathDB; FungiDB:SPAC6G10.12c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_511062_0_0_1; -.
DR InParanoid; O14258; -.
DR OMA; HLRIHEN; -.
DR PhylomeDB; O14258; -.
DR PRO; PR:O14258; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..533
FT /note="Metallothionein expression activator"
FT /id="PRO_0000046799"
FT ZN_FING 443..472
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..500
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..524
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 533 AA; 59842 MW; A352F632746E7001 CRC64;
MSLSYLSSSS QKSFESFRQE ESPACNHSYQ RDYETFGDSK HTSFSSFAPF ENEVSLNQAV
IPSPPSHLQN FQDQFDYSSV LKTPFNPLLE ANSAYFLSNQ ISLPDSHSYA SSFDASLSPP
SSPLTCVSQI HTEQNFNNND AFSLTNSQQA FSEIGYDASN WIDELDSQQQ VLSFPEFDIP
EIKTETCSNK DHLENFDYLS SSIPETSGPA SSVLPSSSQL ESFNEFMFLP SSPPGLDEIN
GAPSFEELNF QISQPSPAHP VDLSSPETAP NISPVSPFAQ LVKLEPTSPQ KPSFALDSSF
SHLDVCRHTD NQKAFAKLSS PAEYVSEFEK FSSVCDHGLD ISNANINNTL TQQFALSAPY
ESCIVTKKPE PCITVKEEEQ LAPKIESADL SITPQVTEHD SKPPVRISYD HRCKTRKQST
RICRIPPETM ASLYCGPEAD GKYVCLYNGC NKRIARKYNV ESHIQTHLSD RPYRCDLCKA
GFVRHHDLKR HLRIHENGRP YVCECLKRFN RLDALNRHKQ RNICVGGVDR RQH
