22P1_RAT
ID 22P1_RAT Reviewed; 176 AA.
AC P22282; Q63674;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Cystatin-related protein 1;
DE Short=CRP-1;
DE AltName: Full=Androgen-regulated 20 kDa protein;
DE AltName: Full=Prostatic 22 kDa glycoprotein P22K16/P22K20;
DE Flags: Precursor;
GN Name=Andpro; Synonyms=Crp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Prostate;
RX PubMed=2280780; DOI=10.1210/mend-4-4-657;
RA Winderickx J., Hemschoote K., de Clercq N., van Dijck P., Peeters B.,
RA Rombauts W., Verhoeven G., Heyns W.;
RT "Tissue-specific expression and androgen regulation of different genes
RT encoding rat prostatic 22-kilodalton glycoproteins homologous to human and
RT rat cystatin.";
RL Mol. Endocrinol. 4:657-667(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-81.
RX PubMed=2477055; DOI=10.1021/bi00441a032;
RA Ho K.-C., Snoek R., Quarmby V., Viskochil D.H., Rennie P.S., Wilson E.M.,
RA French F.S., Bruchovsky N.;
RT "Primary structure and androgen regulation of a 20-kilodalton protein
RT specific to rat ventral prostate.";
RL Biochemistry 28:6367-6373(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar;
RX PubMed=7679983; DOI=10.1210/endo.132.3.7679983;
RA Vercaeren I., Winderickx J., Devos A., Peeters B., Heyns W.;
RT "An effect of androgens on the length of the poly(A)-tail and alternative
RT splicing cause size heterogeneity of the messenger ribonucleic acids
RT encoding cystatin-related protein.";
RL Endocrinology 131:2496-2502(1992).
RN [4]
RP ERRATUM OF PUBMED:7679983.
RA Vercaeren I., Winderickx J., Devos A., Peeters B., Heyns W.;
RL Endocrinology 132:2496-2502(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8462870; DOI=10.1016/0378-1119(93)90323-u;
RA Devos A., de Clercq N., Vercaeren I., Heyns W., Rombauts W., Peeters B.;
RT "Structure of rat genes encoding androgen-regulated cystatin-related
RT proteins (CRPs): a new member of the cystatin superfamily.";
RL Gene 125:159-167(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8262963; DOI=10.1016/s0021-9258(19)74241-0;
RA Ho K.-C., Marschke K.B., Tan J.A., Power S.G.A., Wilson E.M., French F.S.;
RT "A complex response element in intron 1 of the androgen-regulated 20-kDa
RT protein gene displays cell type-dependent androgen receptor specificity.";
RL J. Biol. Chem. 268:27226-27235(1993).
CC -!- TISSUE SPECIFICITY: Prostate and lacrimal gland.
CC -!- INDUCTION: By androgens.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR EMBL; M58167; AAA63498.1; -; mRNA.
DR EMBL; M27901; AAA42345.1; -; mRNA.
DR EMBL; Z13993; CAA78384.1; -; Genomic_DNA.
DR EMBL; S48988; AAA12401.1; -; mRNA.
DR EMBL; S57980; AAB26027.1; -; Genomic_DNA.
DR EMBL; L12454; AAA40732.1; -; Genomic_DNA.
DR PIR; A49304; A49304.
DR RefSeq; NP_036850.1; NM_012718.2.
DR AlphaFoldDB; P22282; -.
DR STRING; 10116.ENSRNOP00000040184; -.
DR GlyGen; P22282; 1 site.
DR iPTMnet; P22282; -.
DR PhosphoSitePlus; P22282; -.
DR PaxDb; P22282; -.
DR GeneID; 25030; -.
DR KEGG; rno:25030; -.
DR UCSC; RGD:2115; rat.
DR CTD; 25030; -.
DR RGD; 2115; Andpro.
DR InParanoid; P22282; -.
DR OrthoDB; 318983at32523; -.
DR PhylomeDB; P22282; -.
DR TreeFam; TF340321; -.
DR PRO; PR:P22282; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:RGD.
DR GO; GO:0005576; C:extracellular region; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0030521; P:androgen receptor signaling pathway; IMP:RGD.
DR GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
DR GO; GO:0071394; P:cellular response to testosterone stimulus; IEP:RGD.
DR GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR CDD; cd00042; CY; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Signal; Thiol protease inhibitor.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..31
FT /evidence="ECO:0000255"
FT /id="PRO_0000006671"
FT CHAIN 32..176
FT /note="Cystatin-related protein 1"
FT /id="PRO_0000006672"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT DISULFID 129..139
FT /evidence="ECO:0000250"
FT DISULFID 153..173
FT /evidence="ECO:0000250"
FT CONFLICT 1..22
FT /note="Missing (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 23..24
FT /note="HA -> MQ (in Ref. 2; AAA42345)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="V -> L (in Ref. 2; AAA42345, 3; CAA78384 and 6;
FT AAA40732)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 21060 MW; 3D5355EC56E3CBA0 CRC64;
MCKTLHGTLL LLAIFVLFLN FSHATAKRTR RGMEIFEKNF IDKNKLKDVY DVFKYLYNTH
SADTYLSNIK NESFTMNIWG FGEIEMVKTK CRKIDSDFYK CSFQREFYNL KRTPGETMYY
ISLPGSVRCR KLLSKLDNCP FEEQTEQLKR EICYFVVYPD YIEQNIHAVR FDCYTK
