CHAC2_BOVIN
ID CHAC2_BOVIN Reviewed; 176 AA.
AC Q0IIH4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Putative glutathione-specific gamma-glutamylcyclotransferase 2 {ECO:0000250|UniProtKB:Q8WUX2};
DE Short=Gamma-GCG 2 {ECO:0000250|UniProtKB:Q8WUX2};
DE EC=4.3.2.7 {ECO:0000250|UniProtKB:Q8WUX2};
DE AltName: Full=Cation transport regulator-like protein 2 {ECO:0000250|UniProtKB:Q9BUX1};
GN Name=CHAC2 {ECO:0000250|UniProtKB:Q8WUX2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline
CC and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on
CC other gamma-glutamyl peptides. {ECO:0000250|UniProtKB:Q8WUX2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine;
CC Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402,
CC ChEBI:CHEBI:61694; EC=4.3.2.7;
CC Evidence={ECO:0000250|UniProtKB:Q8WUX2};
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q8WUX2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q8WUX2}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family. ChaC
CC subfamily. {ECO:0000305}.
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DR EMBL; BC122644; AAI22645.1; -; mRNA.
DR RefSeq; NP_001068996.1; NM_001075528.1.
DR AlphaFoldDB; Q0IIH4; -.
DR SMR; Q0IIH4; -.
DR STRING; 9913.ENSBTAP00000025922; -.
DR PaxDb; Q0IIH4; -.
DR Ensembl; ENSBTAT00000025922; ENSBTAP00000025922; ENSBTAG00000019459.
DR GeneID; 511605; -.
DR KEGG; bta:511605; -.
DR CTD; 494143; -.
DR VEuPathDB; HostDB:ENSBTAG00000019459; -.
DR VGNC; VGNC:27263; CHAC2.
DR eggNOG; KOG3182; Eukaryota.
DR GeneTree; ENSGT00390000003855; -.
DR HOGENOM; CLU_070703_2_2_1; -.
DR InParanoid; Q0IIH4; -.
DR OMA; LLWYTDF; -.
DR OrthoDB; 1238273at2759; -.
DR TreeFam; TF313048; -.
DR Reactome; R-BTA-174403; Glutathione synthesis and recycling.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000019459; Expressed in semitendinosus and 105 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0003839; F:gamma-glutamylcyclotransferase activity; IBA:GO_Central.
DR GO; GO:0061928; F:glutathione specific gamma-glutamylcyclotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006751; P:glutathione catabolic process; IBA:GO_Central.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR006840; ChaC.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12192; PTHR12192; 1.
DR Pfam; PF04752; ChaC; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lyase; Reference proteome.
FT CHAIN 1..176
FT /note="Putative glutathione-specific gamma-
FT glutamylcyclotransferase 2"
FT /id="PRO_0000314911"
FT ACT_SITE 71
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:O75223"
FT BINDING 3..8
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:O75223"
SQ SEQUENCE 176 AA; 20063 MW; 1CE49C9F59441BCC CRC64;
MWVFGYGSLI WKVDFPYQDK LVGYISGYSR RFWQGSTDHR GVPGKGSVWG VAYKLPVGKE
EEVKAYLDFR EKGGYRTTTV IFYPKDSTTE PFSVLLYIGT RDNPNYLGPA PLEDIAEQIF
NAAGPSGKNT EYLFELANSM RSLVPEDADE HLFSLEKLVK ERLEGKQNFN CIKRPN
