CHCH1_HUMAN
ID CHCH1_HUMAN Reviewed; 118 AA.
AC Q96BP2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 1;
DE AltName: Full=28S ribosomal protein S37, mitochondrial;
DE Short=MRP-S37;
DE AltName: Full=Mitochondrial small ribosomal subunit protein mS37 {ECO:0000303|PubMed:25838379};
DE AltName: Full=Nuclear protein C2360;
GN Name=CHCHD1; Synonyms=C10orf34, MRPS37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC TISSUE=Placenta;
RX PubMed=15177562; DOI=10.1016/j.ygeno.2003.12.006;
RA Westerman B.A., Poutsma A., Steegers E.A.P., Oudejans C.B.M.;
RT "C2360, a nuclear protein expressed in human proliferative
RT cytotrophoblasts, is a representative member of a novel protein family with
RT a conserved coiled coil-helix-coiled coil-helix domain.";
RL Genomics 83:1094-1104(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=23908630; DOI=10.3389/fphys.2013.00183;
RA Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E.,
RA Spremulli L.L., Koc H.;
RT "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new
RT members of the mammalian mitochondrial ribosome.";
RL Front. Physiol. 4:183-183(2013).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [6]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. {ECO:0000269|PubMed:23908630,
CC ECO:0000269|PubMed:25838379}.
CC -!- INTERACTION:
CC Q96BP2; Q14696: MESD; NbExp=3; IntAct=EBI-5454898, EBI-6165891;
CC Q96BP2; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-5454898, EBI-742426;
CC Q96BP2; P04618: rev; Xeno; NbExp=3; IntAct=EBI-5454898, EBI-6164309;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23908630}.
CC Nucleus {ECO:0000269|PubMed:15177562}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS37 family. {ECO:0000305}.
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DR EMBL; BC015387; AAH15387.1; -; mRNA.
DR EMBL; BC020852; AAH20852.1; -; mRNA.
DR CCDS; CCDS7334.1; -.
DR RefSeq; NP_976043.1; NM_203298.2.
DR PDB; 3J9M; EM; 3.50 A; A2=1-118.
DR PDB; 6NU2; EM; 3.90 A; A2=2-117.
DR PDB; 6NU3; EM; 4.40 A; A2=1-118.
DR PDB; 6RW4; EM; 2.97 A; 2=2-118.
DR PDB; 6RW5; EM; 3.14 A; 2=2-118.
DR PDB; 6VLZ; EM; 2.97 A; A2=1-118.
DR PDB; 6VMI; EM; 2.96 A; A2=1-118.
DR PDB; 6ZM5; EM; 2.89 A; A2=2-118.
DR PDB; 6ZM6; EM; 2.59 A; A2=2-118.
DR PDB; 6ZS9; EM; 4.00 A; A2=1-118.
DR PDB; 6ZSA; EM; 4.00 A; A2=1-118.
DR PDB; 6ZSB; EM; 4.50 A; A2=1-118.
DR PDB; 6ZSC; EM; 3.50 A; A2=1-118.
DR PDB; 6ZSD; EM; 3.70 A; A2=1-118.
DR PDB; 6ZSE; EM; 5.00 A; A2=1-118.
DR PDB; 6ZSG; EM; 4.00 A; A2=1-118.
DR PDB; 7A5F; EM; 4.40 A; c6=1-118.
DR PDB; 7A5G; EM; 4.33 A; c6=1-118.
DR PDB; 7A5I; EM; 3.70 A; c6=1-118.
DR PDB; 7A5K; EM; 3.70 A; c6=1-118.
DR PDB; 7L08; EM; 3.49 A; A2=1-118.
DR PDB; 7OG4; EM; 3.80 A; A2=1-118.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; Q96BP2; -.
DR SMR; Q96BP2; -.
DR BioGRID; 125612; 237.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q96BP2; 16.
DR MINT; Q96BP2; -.
DR STRING; 9606.ENSP00000361923; -.
DR GlyGen; Q96BP2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96BP2; -.
DR PhosphoSitePlus; Q96BP2; -.
DR BioMuta; CHCHD1; -.
DR DMDM; 62510504; -.
DR EPD; Q96BP2; -.
DR jPOST; Q96BP2; -.
DR MassIVE; Q96BP2; -.
DR MaxQB; Q96BP2; -.
DR PaxDb; Q96BP2; -.
DR PeptideAtlas; Q96BP2; -.
DR PRIDE; Q96BP2; -.
DR ProteomicsDB; 76095; -.
DR Antibodypedia; 45414; 76 antibodies from 22 providers.
DR DNASU; 118487; -.
DR Ensembl; ENST00000372833.6; ENSP00000361923.5; ENSG00000172586.8.
DR GeneID; 118487; -.
DR KEGG; hsa:118487; -.
DR MANE-Select; ENST00000372833.6; ENSP00000361923.5; NM_203298.3; NP_976043.1.
DR UCSC; uc001jvc.5; human.
DR CTD; 118487; -.
DR DisGeNET; 118487; -.
DR GeneCards; CHCHD1; -.
DR HGNC; HGNC:23518; CHCHD1.
DR HPA; ENSG00000172586; Low tissue specificity.
DR MIM; 608842; gene.
DR neXtProt; NX_Q96BP2; -.
DR OpenTargets; ENSG00000172586; -.
DR PharmGKB; PA134964437; -.
DR VEuPathDB; HostDB:ENSG00000172586; -.
DR eggNOG; KOG4695; Eukaryota.
DR GeneTree; ENSGT00390000007683; -.
DR HOGENOM; CLU_146244_1_0_1; -.
DR InParanoid; Q96BP2; -.
DR OMA; QNEKDVP; -.
DR OrthoDB; 1468851at2759; -.
DR PhylomeDB; Q96BP2; -.
DR TreeFam; TF314650; -.
DR PathwayCommons; Q96BP2; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q96BP2; -.
DR SIGNOR; Q96BP2; -.
DR BioGRID-ORCS; 118487; 424 hits in 1085 CRISPR screens.
DR GenomeRNAi; 118487; -.
DR Pharos; Q96BP2; Tbio.
DR PRO; PR:Q96BP2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96BP2; protein.
DR Bgee; ENSG00000172586; Expressed in mucosa of transverse colon and 171 other tissues.
DR ExpressionAtlas; Q96BP2; baseline and differential.
DR Genevisible; Q96BP2; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR033620; CHCHD1.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR PANTHER; PTHR31278; PTHR31278; 1.
DR Pfam; PF06747; CHCH; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Mitochondrion; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..118
FT /note="Coiled-coil-helix-coiled-coil-helix domain-
FT containing protein 1"
FT /id="PRO_0000129158"
FT DOMAIN 42..84
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 45..55
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 66..76
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 45..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 55..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 118 AA; 13475 MW; 98AA1C38045A1C7C CRC64;
MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS VMMACWKQNE
FRDDACRKEI QGFLDCAARA QEARKMRSIQ ETLGESGSLL PNKLNKLLQR FPNKPYLS
