CHCH1_MOUSE
ID CHCH1_MOUSE Reviewed; 118 AA.
AC Q9CQA6; Q56A12;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 1;
DE AltName: Full=28S ribosomal protein S37, mitochondrial;
DE Short=MRP-S37;
GN Name=Chchd1; Synonyms=Mrps37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96BP2}.
CC Nucleus {ECO:0000250|UniProtKB:Q96BP2}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS37 family. {ECO:0000305}.
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DR EMBL; AK003263; BAB22679.1; -; mRNA.
DR EMBL; AK011261; BAB27502.1; -; mRNA.
DR EMBL; BC052720; AAH52720.1; -; mRNA.
DR EMBL; BC092216; AAH92216.1; -; mRNA.
DR CCDS; CCDS26852.1; -.
DR RefSeq; NP_079642.1; NM_025366.3.
DR AlphaFoldDB; Q9CQA6; -.
DR SMR; Q9CQA6; -.
DR BioGRID; 211230; 2.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000071202; -.
DR iPTMnet; Q9CQA6; -.
DR PhosphoSitePlus; Q9CQA6; -.
DR EPD; Q9CQA6; -.
DR MaxQB; Q9CQA6; -.
DR PaxDb; Q9CQA6; -.
DR PRIDE; Q9CQA6; -.
DR ProteomicsDB; 281207; -.
DR Antibodypedia; 45414; 76 antibodies from 22 providers.
DR DNASU; 66121; -.
DR Ensembl; ENSMUST00000071215; ENSMUSP00000071202; ENSMUSG00000063787.
DR GeneID; 66121; -.
DR KEGG; mmu:66121; -.
DR UCSC; uc007skm.2; mouse.
DR CTD; 118487; -.
DR MGI; MGI:1913371; Chchd1.
DR VEuPathDB; HostDB:ENSMUSG00000063787; -.
DR eggNOG; KOG4695; Eukaryota.
DR GeneTree; ENSGT00390000007683; -.
DR HOGENOM; CLU_146244_1_0_1; -.
DR InParanoid; Q9CQA6; -.
DR OMA; QNEKDVP; -.
DR OrthoDB; 1468851at2759; -.
DR PhylomeDB; Q9CQA6; -.
DR TreeFam; TF314650; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66121; 13 hits in 70 CRISPR screens.
DR ChiTaRS; Chchd1; mouse.
DR PRO; PR:Q9CQA6; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9CQA6; protein.
DR Bgee; ENSMUSG00000063787; Expressed in quadriceps femoris and 61 other tissues.
DR ExpressionAtlas; Q9CQA6; baseline and differential.
DR Genevisible; Q9CQA6; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR033620; CHCHD1.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR PANTHER; PTHR31278; PTHR31278; 1.
DR Pfam; PF06747; CHCH; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Mitochondrion; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..118
FT /note="Coiled-coil-helix-coiled-coil-helix domain-
FT containing protein 1"
FT /id="PRO_0000129159"
FT DOMAIN 42..84
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..55
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 66..76
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT COMPBIAS 88..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 45..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 55..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 118 AA; 13608 MW; A819A172F347811A CRC64;
MATPSLRGRL ARFANPGKPI LKPNKPLILA NRVGNRRREK GEATCITEMS MMMACWKQNE
FRDEACRKEI QDFFDCSSRA QEARKMRSIQ ESLGQSESLS PHKMTKLLQR FPNKSHLI
