CHCH5_MOUSE
ID CHCH5_MOUSE Reviewed; 110 AA.
AC Q9CQP3;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 5;
GN Name=Chchd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305}.
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DR EMBL; AK003341; BAB22728.1; -; mRNA.
DR EMBL; AK013018; BAB28600.1; -; mRNA.
DR CCDS; CCDS16721.1; -.
DR RefSeq; NP_079671.1; NM_025395.3.
DR AlphaFoldDB; Q9CQP3; -.
DR SMR; Q9CQP3; -.
DR STRING; 10090.ENSMUSP00000044253; -.
DR PhosphoSitePlus; Q9CQP3; -.
DR EPD; Q9CQP3; -.
DR MaxQB; Q9CQP3; -.
DR PaxDb; Q9CQP3; -.
DR PRIDE; Q9CQP3; -.
DR ProteomicsDB; 279070; -.
DR Antibodypedia; 47917; 213 antibodies from 14 providers.
DR DNASU; 66170; -.
DR Ensembl; ENSMUST00000035481; ENSMUSP00000044253; ENSMUSG00000037938.
DR GeneID; 66170; -.
DR KEGG; mmu:66170; -.
DR UCSC; uc008mhg.2; mouse.
DR CTD; 84269; -.
DR MGI; MGI:1913420; Chchd5.
DR VEuPathDB; HostDB:ENSMUSG00000037938; -.
DR eggNOG; ENOG502S5BR; Eukaryota.
DR GeneTree; ENSGT00390000007919; -.
DR HOGENOM; CLU_165152_0_0_1; -.
DR InParanoid; Q9CQP3; -.
DR OMA; EMEQYGR; -.
DR OrthoDB; 1480151at2759; -.
DR PhylomeDB; Q9CQP3; -.
DR TreeFam; TF333181; -.
DR BioGRID-ORCS; 66170; 12 hits in 72 CRISPR screens.
DR ChiTaRS; Chchd5; mouse.
DR PRO; PR:Q9CQP3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQP3; protein.
DR Bgee; ENSMUSG00000037938; Expressed in morula and 214 other tissues.
DR ExpressionAtlas; Q9CQP3; baseline and differential.
DR Genevisible; Q9CQP3; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0045333; P:cellular respiration; IBA:GO_Central.
DR InterPro; IPR031731; CX9C.
DR Pfam; PF16860; CX9C; 1.
DR PROSITE; PS51808; CHCH; 2.
PE 1: Evidence at protein level;
KW Acetylation; Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..110
FT /note="Coiled-coil-helix-coiled-coil-helix domain-
FT containing protein 5"
FT /id="PRO_0000129168"
FT DOMAIN 9..52
FT /note="CHCH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DOMAIN 55..97
FT /note="CHCH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 12..22
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 34..44
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 58..68
FT /note="Cx9C motif 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 79..89
FT /note="Cx9C motif 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSY4"
FT DISULFID 12..44
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 22..34
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 58..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 68..79
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 110 AA; 12326 MW; 6EBFD626973C65B7 CRC64;
MQAALEVTAR YCSRELDQYG QCVAAKPESW HRDCHHLKMS IARCTSSHPI IRQIRQACAE
PFEAFEKCLR LNEAAVGNCA EHMRRFLQCA EQVQPPSSPT TGEAQPLPAS
