CHCH7_MOUSE
ID CHCH7_MOUSE Reviewed; 85 AA.
AC Q8K2Q5; Q3TGP4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 7;
GN Name=Chchd7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CHCHD7 family. {ECO:0000305}.
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DR EMBL; AK003308; BAC25029.1; -; mRNA.
DR EMBL; AK007844; BAC25190.1; -; mRNA.
DR EMBL; AK145105; BAE26238.1; -; mRNA.
DR EMBL; AK168647; BAE40504.1; -; mRNA.
DR EMBL; BC030366; AAH30366.1; -; mRNA.
DR CCDS; CCDS38686.1; -.
DR RefSeq; NP_001177251.1; NM_001190322.2.
DR RefSeq; NP_001177252.1; NM_001190323.2.
DR RefSeq; NP_001177253.1; NM_001190324.2.
DR RefSeq; NP_001272733.1; NM_001285804.1.
DR RefSeq; NP_852056.1; NM_181391.4.
DR RefSeq; XP_017175837.1; XM_017320348.1.
DR RefSeq; XP_017175838.1; XM_017320349.1.
DR AlphaFoldDB; Q8K2Q5; -.
DR SMR; Q8K2Q5; -.
DR STRING; 10090.ENSMUSP00000041196; -.
DR PhosphoSitePlus; Q8K2Q5; -.
DR EPD; Q8K2Q5; -.
DR MaxQB; Q8K2Q5; -.
DR PaxDb; Q8K2Q5; -.
DR PRIDE; Q8K2Q5; -.
DR ProteomicsDB; 279071; -.
DR Antibodypedia; 42406; 57 antibodies from 22 providers.
DR DNASU; 66433; -.
DR Ensembl; ENSMUST00000041122; ENSMUSP00000041196; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000108386; ENSMUSP00000104023; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000119307; ENSMUSP00000113811; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000119403; ENSMUSP00000113613; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000121110; ENSMUSP00000113276; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000121651; ENSMUSP00000112967; ENSMUSG00000042198.
DR Ensembl; ENSMUST00000150618; ENSMUSP00000118860; ENSMUSG00000042198.
DR GeneID; 66433; -.
DR KEGG; mmu:66433; -.
DR UCSC; uc008rwq.2; mouse.
DR CTD; 79145; -.
DR MGI; MGI:1913683; Chchd7.
DR VEuPathDB; HostDB:ENSMUSG00000042198; -.
DR eggNOG; KOG4618; Eukaryota.
DR GeneTree; ENSGT00390000001029; -.
DR InParanoid; Q8K2Q5; -.
DR OMA; NYDKERC; -.
DR OrthoDB; 1617584at2759; -.
DR PhylomeDB; Q8K2Q5; -.
DR TreeFam; TF300284; -.
DR BioGRID-ORCS; 66433; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Chchd7; mouse.
DR PRO; PR:Q8K2Q5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K2Q5; protein.
DR Bgee; ENSMUSG00000042198; Expressed in interventricular septum and 265 other tissues.
DR ExpressionAtlas; Q8K2Q5; baseline and differential.
DR Genevisible; Q8K2Q5; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..85
FT /note="Coiled-coil-helix-coiled-coil-helix domain-
FT containing protein 7"
FT /id="PRO_0000129173"
FT DOMAIN 13..55
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 16..26
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 37..47
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 16..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 26..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 85 AA; 10102 MW; 5CF4CC8012404BB9 CRC64;
MPMVTRRLRD PDINPCLSES DASTRCMDEN NYDRERCSSY FLKYKNCRRF WNSVMIQRRQ
NGVQPSMPTA AERDEILGAM QKMPY
