ID   CHED1_METMA             Reviewed;         221 AA.
AC   Q8Q012;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable chemoreceptor glutamine deamidase CheD 1 {ECO:0000255|HAMAP-Rule:MF_01440};
DE            EC=3.5.1.44 {ECO:0000255|HAMAP-Rule:MF_01440};
GN   Name=cheD1 {ECO:0000255|HAMAP-Rule:MF_01440}; OrderedLocusNames=MM_0326;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Probably deamidates glutamine residues to glutamate on
CC       methyl-accepting chemotaxis receptors (MCPs), playing an important role
CC       in chemotaxis. {ECO:0000255|HAMAP-Rule:MF_01440}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+);
CC         Xref=Rhea:RHEA:16441, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:10208,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29973,
CC         ChEBI:CHEBI:30011; EC=3.5.1.44; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01440};
CC   -!- SIMILARITY: Belongs to the CheD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01440}.
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DR   EMBL; AE008384; AAM30022.1; -; Genomic_DNA.
DR   RefSeq; WP_011032280.1; NC_003901.1.
DR   AlphaFoldDB; Q8Q012; -.
DR   SMR; Q8Q012; -.
DR   STRING; 192952.MM_0326; -.
DR   EnsemblBacteria; AAM30022; AAM30022; MM_0326.
DR   GeneID; 44086474; -.
DR   GeneID; 66134940; -.
DR   KEGG; mma:MM_0326; -.
DR   PATRIC; fig|192952.21.peg.398; -.
DR   eggNOG; arCOG02380; Archaea.
DR   HOGENOM; CLU_087854_2_0_2; -.
DR   OMA; RIGGMCH; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0050568; F:protein-glutamine glutaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-UniRule.
DR   CDD; cd16352; CheD; 1.
DR   Gene3D; 3.30.1330.200; -; 1.
DR   HAMAP; MF_01440; CheD; 1.
DR   InterPro; IPR038592; CheD-like_sf.
DR   InterPro; IPR005659; Chemorcpt_Glu_NH3ase_CheD.
DR   InterPro; IPR011324; Cytotoxic_necrot_fac-like_cat.
DR   PANTHER; PTHR35147; PTHR35147; 1.
DR   Pfam; PF03975; CheD; 1.
DR   SUPFAM; SSF64438; SSF64438; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Hydrolase; Reference proteome.
FT   CHAIN           1..221
FT                   /note="Probable chemoreceptor glutamine deamidase CheD 1"
FT                   /id="PRO_0000251092"
SQ   SEQUENCE   221 AA;  23513 MW;  4456F68568368697 CRC64;
     MSSVFLFISN ESGKAIFLIS GDVLVKSFCS LSDTCPFQDS CRSCSLLNAA KNYLAGTAPD
     SRIKTLDGEL SAGIGEYKIG KNVLLKVMGL GSCIGVILSD VSTGICGIAH VLLPGASDRG
     ETKYAETAIE KMVEDMVKMG ARRSRITAKF AGGAQVFKHM SLDILKIGDR NAISVEETLI
     KKNIPILAKD VGGEVGRNVI FNPADGSMIV KYTAKGEVLW L