CHED2_METMA
ID CHED2_METMA Reviewed; 159 AA.
AC Q8PXA0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Probable chemoreceptor glutamine deamidase CheD 2 {ECO:0000255|HAMAP-Rule:MF_01440};
DE EC=3.5.1.44 {ECO:0000255|HAMAP-Rule:MF_01440};
GN Name=cheD2 {ECO:0000255|HAMAP-Rule:MF_01440}; OrderedLocusNames=MM_1322;
OS Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS 11833 / OCM 88) (Methanosarcina frisia).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=192952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC -!- FUNCTION: Probably deamidates glutamine residues to glutamate on
CC methyl-accepting chemotaxis receptors (MCPs), playing an important role
CC in chemotaxis. {ECO:0000255|HAMAP-Rule:MF_01440}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+);
CC Xref=Rhea:RHEA:16441, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:10208,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29973,
CC ChEBI:CHEBI:30011; EC=3.5.1.44; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01440};
CC -!- SIMILARITY: Belongs to the CheD family. {ECO:0000255|HAMAP-
CC Rule:MF_01440}.
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DR EMBL; AE008384; AAM31018.1; -; Genomic_DNA.
DR RefSeq; WP_011033268.1; NC_003901.1.
DR AlphaFoldDB; Q8PXA0; -.
DR SMR; Q8PXA0; -.
DR STRING; 192952.MM_1322; -.
DR EnsemblBacteria; AAM31018; AAM31018; MM_1322.
DR GeneID; 44089063; -.
DR KEGG; mma:MM_1322; -.
DR PATRIC; fig|192952.21.peg.1535; -.
DR eggNOG; arCOG02380; Archaea.
DR HOGENOM; CLU_087854_2_0_2; -.
DR OMA; VGMADLN; -.
DR Proteomes; UP000000595; Chromosome.
DR GO; GO:0050568; F:protein-glutamine glutaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-UniRule.
DR CDD; cd16352; CheD; 1.
DR Gene3D; 3.30.1330.200; -; 1.
DR HAMAP; MF_01440; CheD; 1.
DR InterPro; IPR038592; CheD-like_sf.
DR InterPro; IPR005659; Chemorcpt_Glu_NH3ase_CheD.
DR InterPro; IPR011324; Cytotoxic_necrot_fac-like_cat.
DR PANTHER; PTHR35147; PTHR35147; 1.
DR Pfam; PF03975; CheD; 1.
DR SUPFAM; SSF64438; SSF64438; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Hydrolase; Reference proteome.
FT CHAIN 1..159
FT /note="Probable chemoreceptor glutamine deamidase CheD 2"
FT /id="PRO_0000251093"
SQ SEQUENCE 159 AA; 17196 MW; 246531FC49B0C913 CRC64;
MVNSDIITVG IGDCAIARSP MKIKTSGLGS CLGITLYDRQ KKIGGLLHTM LPNIKDAKLK
DNPAKFTDAG IEYLVDEMIR RGGSIDKLEA KVVGGAGMFE NSRLNIGERN IKSARETMKK
LGVSIIAEDV GKNYGRTVIF DTLTGDLLIK TILKGDKLI