ID   CHED_ALKHC              Reviewed;         162 AA.
AC   Q9KA57;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Chemoreceptor glutamine deamidase CheD {ECO:0000255|HAMAP-Rule:MF_01440};
DE            EC=3.5.1.44 {ECO:0000255|HAMAP-Rule:MF_01440};
GN   Name=cheD {ECO:0000255|HAMAP-Rule:MF_01440}; OrderedLocusNames=BH2433;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Deamidates glutamine residues to glutamate on methyl-
CC       accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is
CC       required for productive communication of the conformational signals of
CC       the chemoreceptors to the CheA kinase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+);
CC         Xref=Rhea:RHEA:16441, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:10208,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29973,
CC         ChEBI:CHEBI:30011; EC=3.5.1.44; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01440};
CC   -!- SUBUNIT: Forms a complex with CheC. {ECO:0000255|HAMAP-Rule:MF_01440}.
CC   -!- SIMILARITY: Belongs to the CheD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01440}.
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DR   EMBL; BA000004; BAB06152.1; -; Genomic_DNA.
DR   PIR; A83954; A83954.
DR   RefSeq; WP_010898586.1; NC_002570.2.
DR   AlphaFoldDB; Q9KA57; -.
DR   SMR; Q9KA57; -.
DR   STRING; 272558.10175053; -.
DR   EnsemblBacteria; BAB06152; BAB06152; BAB06152.
DR   KEGG; bha:BH2433; -.
DR   eggNOG; COG1871; Bacteria.
DR   HOGENOM; CLU_087854_2_0_9; -.
DR   OMA; VGMADLN; -.
DR   OrthoDB; 1863047at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0050568; F:protein-glutamine glutaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-UniRule.
DR   CDD; cd16352; CheD; 1.
DR   Gene3D; 3.30.1330.200; -; 1.
DR   HAMAP; MF_01440; CheD; 1.
DR   InterPro; IPR038592; CheD-like_sf.
DR   InterPro; IPR005659; Chemorcpt_Glu_NH3ase_CheD.
DR   InterPro; IPR011324; Cytotoxic_necrot_fac-like_cat.
DR   PANTHER; PTHR35147; PTHR35147; 1.
DR   Pfam; PF03975; CheD; 1.
DR   SUPFAM; SSF64438; SSF64438; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Hydrolase; Reference proteome.
FT   CHAIN           1..162
FT                   /note="Chemoreceptor glutamine deamidase CheD"
FT                   /id="PRO_0000251003"
SQ   SEQUENCE   162 AA;  17629 MW;  97910AC0BEBE5C85 CRC64;
     MNDVVKVGMA DLNVVTPPHT IRTAGLGSCV GVVLYDDVKK VAGMAHIMLP DSALGKKQEF
     NRAKYADTAL DLLLSKLEAI GAKRYSLKAK MAGGAQMFSF ASNNDMMRIG QRNVEAVKKK
     LRELSIPILA EDVGGSNGRT IEFNPETKRL SIRTVHQGEK EI