ID   CHEW_ECO57              Reviewed;         167 AA.
AC   P0A966; P07365;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Chemotaxis protein CheW;
GN   Name=cheW; OrderedLocusNames=Z2941, ECs2597;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the transmission of sensory signals from the
CC       chemoreceptors to the flagellar motors. It physically bridges CheA to
CC       the MCPs (methyl-accepting chemotaxis proteins) to allow regulated
CC       phosphotransfer to CheY and CheB (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: An in vitro complex of CheW/CheA(L)/CheA(S) in a 1:1:1 ratio
CC       increases the autophosphorylation of CheA and is required for the
CC       binding of CheY, the phosphorylation substrate. This complex accounts
CC       for 10% of the total number of molecules (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AE005174; AAG56877.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36020.1; -; Genomic_DNA.
DR   PIR; E90953; E90953.
DR   RefSeq; NP_310624.1; NC_002695.1.
DR   RefSeq; WP_000147302.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0A966; -.
DR   BMRB; P0A966; -.
DR   SMR; P0A966; -.
DR   STRING; 155864.EDL933_2862; -.
DR   EnsemblBacteria; AAG56877; AAG56877; Z2941.
DR   EnsemblBacteria; BAB36020; BAB36020; ECs_2597.
DR   GeneID; 66674222; -.
DR   GeneID; 914106; -.
DR   KEGG; ece:Z2941; -.
DR   KEGG; ecs:ECs_2597; -.
DR   PATRIC; fig|386585.9.peg.2723; -.
DR   eggNOG; COG0835; Bacteria.
DR   HOGENOM; CLU_048995_1_0_6; -.
DR   OMA; CVNIMSV; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR039315; CheW.
DR   InterPro; IPR036061; CheW-like_dom_sf.
DR   InterPro; IPR002545; CheW-lke_dom.
DR   PANTHER; PTHR22617; PTHR22617; 1.
DR   Pfam; PF01584; CheW; 1.
DR   SMART; SM00260; CheW; 1.
DR   SUPFAM; SSF50341; SSF50341; 1.
DR   PROSITE; PS50851; CHEW; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytoplasm; Reference proteome.
FT   CHAIN           1..167
FT                   /note="Chemotaxis protein CheW"
FT                   /id="PRO_0000198342"
FT   DOMAIN          16..156
FT                   /note="CheW-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00052"
SQ   SEQUENCE   167 AA;  18084 MW;  9CE642E5F4E91BFF CRC64;
     MTGMTNVTKL ASEPSGQEFL VFTLGDEEYG IDILKVQEIR GYDQVTRIAN TPAFIKGVTN
     LRGVIVPIVD LRIKFSQVDV DYNDNTVVIV LNLGQRVVGI VVDGVSDVLS LTAEQIRPAP
     EFAVTLSTEY LTGLGALGDR MLILVNIEKL LNSEEMALLD SAASEVA