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CHEW_HELPY
ID   CHEW_HELPY              Reviewed;         165 AA.
AC   O25152;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Chemotaxis protein CheW {ECO:0000303|PubMed:11535789};
GN   Name=cheW {ECO:0000303|PubMed:11535789}; OrderedLocusNames=HP_0391;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=11535789; DOI=10.1099/00221287-147-9-2493;
RA   Pittman M.S., Goodwin M., Kelly D.J.;
RT   "Chemotaxis in the human gastric pathogen Helicobacter pylori: different
RT   roles for CheW and the three CheV paralogues, and evidence for CheV2
RT   phosphorylation.";
RL   Microbiology 147:2493-2504(2001).
CC   -!- FUNCTION: Plays an essential role in chemotaxis signal transduction
CC       system in order to colonize the host stomach.
CC       {ECO:0000269|PubMed:11535789}.
CC   -!- INTERACTION:
CC       O25152; O25153: cheAY; NbExp=3; IntAct=EBI-7496390, EBI-6410665;
CC       O25152; O25606: HP_0952; NbExp=3; IntAct=EBI-7496390, EBI-9260819;
CC   -!- DISRUPTION PHENOTYPE: Deletion abolishes swarming.
CC       {ECO:0000269|PubMed:11535789}.
CC   -!- SIMILARITY: Belongs to the CheW family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07456.1; -; Genomic_DNA.
DR   PIR; G64568; G64568.
DR   RefSeq; NP_207189.1; NC_000915.1.
DR   RefSeq; WP_000070768.1; NC_018939.1.
DR   AlphaFoldDB; O25152; -.
DR   SMR; O25152; -.
DR   DIP; DIP-3415N; -.
DR   IntAct; O25152; 4.
DR   MINT; O25152; -.
DR   STRING; 85962.C694_01985; -.
DR   PaxDb; O25152; -.
DR   DNASU; 900081; -.
DR   EnsemblBacteria; AAD07456; AAD07456; HP_0391.
DR   KEGG; hpy:HP_0391; -.
DR   PATRIC; fig|85962.47.peg.415; -.
DR   eggNOG; COG0835; Bacteria.
DR   OMA; CVNIMSV; -.
DR   PhylomeDB; O25152; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR039315; CheW.
DR   InterPro; IPR036061; CheW-like_dom_sf.
DR   InterPro; IPR002545; CheW-lke_dom.
DR   PANTHER; PTHR22617; PTHR22617; 1.
DR   Pfam; PF01584; CheW; 1.
DR   SMART; SM00260; CheW; 1.
DR   SUPFAM; SSF50341; SSF50341; 1.
DR   PROSITE; PS50851; CHEW; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..165
FT                   /note="Chemotaxis protein CheW"
FT                   /id="PRO_0000448748"
SQ   SEQUENCE   165 AA;  18967 MW;  9743BBD172C2F6A5 CRC64;
     MSNQLKDLFE RQKEASAGSK QEDNEEVLQF IGFIIGDEEY AIPILNILEI VKPIGYTRVP
     ETPNYVLGVF NLRGNVFPLI SLRLKFGLKA EKQNKDTRYL VVRHNDQIAG FFIDRLTEAI
     RIKQTDIDPV PETLSDNNNL TYGIGKQNDR LVTILRVEEI LKKDF
 
 
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