ID   CHEW_THEMA              Reviewed;         151 AA.
AC   Q56311;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 135.
DE   RecName: Full=Chemotaxis protein CheW;
GN   Name=cheW; OrderedLocusNames=TM_0701;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8550470; DOI=10.1128/jb.178.2.484-489.1996;
RA   Swanson R.V., Sanna M.G., Simon M.I.;
RT   "Thermostable chemotaxis proteins from the hyperthermophilic bacterium
RT   Thermotoga maritima.";
RL   J. Bacteriol. 178:484-489(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: Involved in the transmission of sensory signals from the
CC       chemoreceptors to the flagellar motors. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q56311; Q56310: cheA; NbExp=3; IntAct=EBI-15580256, EBI-1039701;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; U30501; AAA96388.1; -; Genomic_DNA.
DR   EMBL; AE000512; AAD35783.1; -; Genomic_DNA.
DR   PIR; C72346; C72346.
DR   RefSeq; NP_228510.1; NC_000853.1.
DR   RefSeq; WP_010865187.1; NC_023151.1.
DR   PDB; 1K0S; NMR; -; A=1-151.
DR   PDB; 2CH4; X-ray; 3.50 A; W/Y=1-151.
DR   PDB; 3JA6; EM; 12.70 A; A/B/D/F=9-147.
DR   PDB; 3UR1; X-ray; 4.50 A; B=9-147.
DR   PDB; 4JPB; X-ray; 3.19 A; W=1-147.
DR   PDBsum; 1K0S; -.
DR   PDBsum; 2CH4; -.
DR   PDBsum; 3JA6; -.
DR   PDBsum; 3UR1; -.
DR   PDBsum; 4JPB; -.
DR   AlphaFoldDB; Q56311; -.
DR   BMRB; Q56311; -.
DR   SMR; Q56311; -.
DR   DIP; DIP-29073N; -.
DR   IntAct; Q56311; 1.
DR   STRING; 243274.THEMA_01160; -.
DR   EnsemblBacteria; AAD35783; AAD35783; TM_0701.
DR   KEGG; tma:TM0701; -.
DR   PATRIC; fig|243274.18.peg.226; -.
DR   eggNOG; COG0835; Bacteria.
DR   InParanoid; Q56311; -.
DR   OMA; DEEYGVE; -.
DR   EvolutionaryTrace; Q56311; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:CAFA.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   DisProt; DP00350; -.
DR   InterPro; IPR039315; CheW.
DR   InterPro; IPR036061; CheW-like_dom_sf.
DR   InterPro; IPR002545; CheW-lke_dom.
DR   PANTHER; PTHR22617; PTHR22617; 1.
DR   Pfam; PF01584; CheW; 1.
DR   SMART; SM00260; CheW; 1.
DR   SUPFAM; SSF50341; SSF50341; 1.
DR   PROSITE; PS50851; CHEW; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chemotaxis; Cytoplasm; Reference proteome.
FT   CHAIN           1..151
FT                   /note="Chemotaxis protein CheW"
FT                   /id="PRO_0000198349"
FT   DOMAIN          10..147
FT                   /note="CheW-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00052"
FT   STRAND          10..20
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          22..26
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   HELIX           27..29
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          30..35
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          46..48
FT                   /evidence="ECO:0007829|PDB:1K0S"
FT   STRAND          49..55
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          58..64
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   HELIX           65..69
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   HELIX           75..77
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          80..86
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          89..105
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          108..110
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   TURN            113..115
FT                   /evidence="ECO:0007829|PDB:2CH4"
FT   STRAND          116..118
FT                   /evidence="ECO:0007829|PDB:2CH4"
FT   HELIX           119..121
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          122..128
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   STRAND          131..136
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   HELIX           138..145
FT                   /evidence="ECO:0007829|PDB:4JPB"
FT   TURN            148..150
FT                   /evidence="ECO:0007829|PDB:1K0S"
SQ   SEQUENCE   151 AA;  16955 MW;  122A5EFEDFA3D561 CRC64;
     MKTLADALKE FEVLSFEIDE QALAFDVDNI EMVIEKSDIT PVPKSRHFVE GVINLRGRII
     PVVNLAKILG ISFDEQKMKS IIVARTKDVE VGFLVDRVLG VLRITENQLD LTNVSDKFGK
     KSKGLVKTDG RLIIYLDIDK IIEEITVKEG V