CHEZ_ECO5T
ID CHEZ_ECO5T Reviewed; 214 AA.
AC C6UY58;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Protein phosphatase CheZ;
DE EC=3.1.3.-;
DE AltName: Full=Chemotaxis protein CheZ;
GN Name=cheZ; OrderedLocusNames=ECSP_2455;
OS Escherichia coli O157:H7 (strain TW14359 / EHEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=544404;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW14359 / EHEC;
RX PubMed=19564389; DOI=10.1128/iai.00198-09;
RA Kulasekara B.R., Jacobs M., Zhou Y., Wu Z., Sims E., Saenphimmachak C.,
RA Rohmer L., Ritchie J.M., Radey M., McKevitt M., Freeman T.L., Hayden H.,
RA Haugen E., Gillett W., Fong C., Chang J., Beskhlebnaya V., Waldor M.K.,
RA Samadpour M., Whittam T.S., Kaul R., Brittnacher M., Miller S.I.;
RT "Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-
RT associated outbreak isolate indicates candidate genes that may enhance
RT virulence.";
RL Infect. Immun. 77:3713-3721(2009).
CC -!- FUNCTION: Plays an important role in bacterial chemotaxis signal
CC transduction pathway by accelerating the dephosphorylation of
CC phosphorylated CheY (CheY-P). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CheZ family. {ECO:0000305}.
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DR EMBL; CP001368; ACT72266.1; -; Genomic_DNA.
DR RefSeq; WP_000983602.1; NC_013008.1.
DR AlphaFoldDB; C6UY58; -.
DR SMR; C6UY58; -.
DR KEGG; etw:ECSP_2455; -.
DR HOGENOM; CLU_080718_1_0_6; -.
DR OMA; EGPQIHA; -.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR GO; GO:0097588; P:archaeal or bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0050920; P:regulation of chemotaxis; IEA:InterPro.
DR InterPro; IPR007439; Chemotax_Pase_CheZ.
DR Pfam; PF04344; CheZ; 1.
DR PIRSF; PIRSF002884; CheZ; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytoplasm; Flagellar rotation; Hydrolase; Protein phosphatase.
FT CHAIN 1..214
FT /note="Protein phosphatase CheZ"
FT /id="PRO_0000410777"
FT REGION 174..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 147
FT /note="Enhances dephosphorylation of CheY-P"
FT /evidence="ECO:0000250"
SQ SEQUENCE 214 AA; 23976 MW; A3E29BF134D716D3 CRC64;
MMQPSIKPAD EHSAGDIIAR IGSLTRMLRD SLRELGLDQA IAEAAEAIPD ARDRLYYVVQ
MTAQAAERAL NSVEASQPHQ DQMEKSAKAL TQRWDDWFAD PIDLADAREL VTDTRKFLAD
VPAHTSFTNA QLLEIMMAQD FQDLTGQVIK RMMDVIQEIE RQLLMVLLEN IPEQESRPKR
ENQSLLNGPQ VDTSKAGVVA SQDQVDDLLD SLGF