CHEZ_PSEAE
ID CHEZ_PSEAE Reviewed; 227 AA.
AC Q51434;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein phosphatase CheZ;
DE EC=3.1.3.-;
DE AltName: Full=Chemotaxis protein CheZ;
GN Name=cheZ; OrderedLocusNames=PA1457;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=7860605; DOI=10.1128/jb.177.4.948-952.1995;
RA Masduki A., Nakamura J., Ohga T., Umezaki R., Kato J., Ohtake H.;
RT "Isolation and characterization of chemotaxis mutants and genes of
RT Pseudomonas aeruginosa.";
RL J. Bacteriol. 177:948-952(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10052136; DOI=10.1271/bbb.63.155;
RA Kato J., Nakamura T., Kuroda A., Ohtake H.;
RT "Cloning and characterization of chemotaxis genes in Pseudomonas
RT aeruginosa.";
RL Biosci. Biotechnol. Biochem. 63:155-161(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Plays an important role in bacterial chemotaxis signal
CC transduction pathway by accelerating the dephosphorylation of
CC phosphorylated CheY (CheY-P). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CheZ family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG04846.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D37810; BAA07056.1; -; Genomic_DNA.
DR EMBL; AB012767; BAA33548.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04846.1; ALT_INIT; Genomic_DNA.
DR PIR; E83463; E83463.
DR PIR; T46613; T46613.
DR RefSeq; NP_250148.1; NC_002516.2.
DR AlphaFoldDB; Q51434; -.
DR SMR; Q51434; -.
DR STRING; 287.DR97_566; -.
DR PaxDb; Q51434; -.
DR PRIDE; Q51434; -.
DR DNASU; 880861; -.
DR EnsemblBacteria; AAG04846; AAG04846; PA1457.
DR GeneID; 880861; -.
DR KEGG; pae:PA1457; -.
DR PATRIC; fig|208964.12.peg.1508; -.
DR PseudoCAP; PA1457; -.
DR HOGENOM; CLU_080718_0_0_6; -.
DR InParanoid; Q51434; -.
DR OMA; EGPQIHA; -.
DR PhylomeDB; Q51434; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:PseudoCAP.
DR GO; GO:0006935; P:chemotaxis; IMP:PseudoCAP.
DR GO; GO:0050920; P:regulation of chemotaxis; IEA:InterPro.
DR InterPro; IPR007439; Chemotax_Pase_CheZ.
DR Pfam; PF04344; CheZ; 1.
DR PIRSF; PIRSF002884; CheZ; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytoplasm; Flagellar rotation; Hydrolase; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1..227
FT /note="Protein phosphatase CheZ"
FT /id="PRO_0000089642"
FT REGION 194..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 147
FT /note="Enhances dephosphorylation of CheY-P"
FT /evidence="ECO:0000250"
FT CONFLICT 59
FT /note="V -> E (in Ref. 1; BAA07056 and 2; BAA33548)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="S -> T (in Ref. 1; BAA07056 and 2; BAA33548)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="L -> M (in Ref. 1; BAA07056 and 2; BAA33548)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 25710 MW; A073CACF9FBB91C9 CRC64;
MQLIQELSQA RDRGLYQEVG KLTRELHNAI VDFQIDPHSP HAQEMSQIAD ATDRLSYVVE
MTEKAANRTM DLVEQSAPLV NQLGDDSREL HQEWQRFMRR EIDADGFREL AKRIEQFLVR
SGENAGQLSS QLNDILLAQD YQDLTGQVIK RVTKLVTEVE SNLVKLVWMA GQVDRYAGIE
HDHVSMRHQA ALERSAKGEG PQVAAEKRED VVSGQDDVDD LLSSLGF
