CHH1_FAXLI
ID CHH1_FAXLI Reviewed; 135 AA.
AC Q25589;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Crustacean hyperglycemic hormones A;
DE Short=CHH A;
DE Contains:
DE RecName: Full=CHH precursor-related peptide A;
DE Short=CPRP A;
DE Contains:
DE RecName: Full=Crustacean hyperglycemic hormone;
DE Short=CHH;
DE Flags: Precursor;
GN Name=CHHA;
OS Faxonius limosus (Spinycheek crayfish) (Orconectes limosus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC Astacoidea; Cambaridae; Faxonius.
OX NCBI_TaxID=28379;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eyestalk;
RX PubMed=7925379; DOI=10.1111/j.1432-1033.1994.00623.x;
RA de Kleijn D.P.V., Janssen K.P.C., Martens G.J.M., van Herp F.;
RT "Cloning and expression of two crustacean hyperglycemic-hormone mRNAs in
RT the eyestalk of the crayfish Orconectes limosus.";
RL Eur. J. Biochem. 224:623-629(1994).
RN [2]
RP PROTEIN SEQUENCE OF 27-59.
RC TISSUE=Sinus gland;
RX PubMed=1788131; DOI=10.1016/0196-9781(91)90119-a;
RA Tensen C.P., Verhoeven A.H.M., Gaus G., Janssen K.P.C., Keller R.,
RA van Herp F.;
RT "Isolation and amino acid sequence of crustacean hyperglycemic hormone
RT precursor-related peptides.";
RL Peptides 12:673-681(1991).
RN [3]
RP PROTEIN SEQUENCE OF 62-133, PYROGLUTAMATE FORMATION AT GLN-62, AND
RP AMIDATION AT VAL-133.
RC TISSUE=Sinus gland;
RX PubMed=1800954; DOI=10.1016/0196-9781(91)90036-o;
RA Kegel G., Reichwein B., Tensen C.P., Keller R.;
RT "Amino acid sequence of crustacean hyperglycemic hormone (CHH) from the
RT crayfish, Orconectes limosus: emergence of a novel neuropeptide family.";
RL Peptides 12:909-913(1991).
CC -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC which controls the blood sugar level. Has a secretagogue action over
CC the amylase released from the midgut gland. May act as a stress hormone
CC and may be involved in the control of molting and reproduction.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC eyestalks and transported to the sinus gland where they are stored and
CC released.
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR EMBL; X78562; CAA55308.1; -; mRNA.
DR PIR; S48141; S48141.
DR AlphaFoldDB; Q25589; -.
DR SMR; Q25589; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR000346; Hyperglycemic1.
DR PANTHER; PTHR35981; PTHR35981; 1.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00548; HYPRGLYCEMC1.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 1: Evidence at protein level;
KW Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone;
KW Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:1788131"
FT PEPTIDE 27..59
FT /note="CHH precursor-related peptide A"
FT /id="PRO_0000019047"
FT PEPTIDE 62..133
FT /note="Crustacean hyperglycemic hormone"
FT /id="PRO_0000019048"
FT MOD_RES 62
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:1800954"
FT MOD_RES 133
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:1800954"
FT DISULFID 68..104
FT /evidence="ECO:0000250"
FT DISULFID 84..100
FT /evidence="ECO:0000250"
FT DISULFID 87..113
FT /evidence="ECO:0000250"
SQ SEQUENCE 135 AA; 15086 MW; 61D42FA4A7FCF56A CRC64;
MVSFRTMWSL VVVVVVASLA SSGVQGRSVE GSSRMERLLS SGSSSSEPLS FLSQDQSVSK
RQVFDQACKG IYDRAIFKKL DRVCEDCYNL YRKPYVATTC RQNCYANSVF RQCLDDLLLI
DVLDEYISGV QTVGK
