ID   CHH1_MACRS              Reviewed;          71 AA.
AC   P81206;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Crustacean hyperglycemic hormone isoform 1;
DE   AltName: Full=Crustacean hyperglycemic hormone isoform I;
DE   AltName: Full=MAR-CHH-I;
DE            Short=CHH I;
OS   Macrobrachium rosenbergii (Giant fresh water prawn).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Caridea;
OC   Palaemonoidea; Palaemonidae; Macrobrachium.
OX   NCBI_TaxID=79674;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Eyestalk;
RX   PubMed=10404650;
RX   DOI=10.1002/(sici)1097-010x(19990701)284:2<217::aid-jez11>3.3.co;2-x;
RA   Sithigorngul W., Jaideechoey S., Saraithongkum W., Longyant S.,
RA   Sithigorngul P.;
RT   "Purification and characterization of an isoform of crustacean
RT   hyperglycemic hormone from the eyestalk of Macrobrachium rosenbergii.";
RL   J. Exp. Zool. 284:217-224(1999).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P81206; -.
DR   SMR; P81206; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; Direct protein sequencing;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..71
FT                   /note="Crustacean hyperglycemic hormone isoform 1"
FT                   /id="PRO_0000209859"
FT   MOD_RES         71
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8432 MW;  7EAB0EE8BFC2F3C6 CRC64;
     AILDQSCKGI FDRELFKKLD RVCDDCYNLY RKPYVAIDCR RGCYQNLVFR QCIQDLQLMD
     DLDEYANAVQ V