ID   CHH2_PENMO              Reviewed;         118 AA.
AC   O97384; O96678;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Crustacean hyperglycemic hormones 2;
DE   AltName: Full=Pm-SGP-II;
DE   Contains:
DE     RecName: Full=CHH precursor-related peptide 2;
DE              Short=CPRP 2;
DE   Contains:
DE     RecName: Full=Crustacean hyperglycemic hormone 2;
DE              Short=CHH 2;
DE   Flags: Precursor;
GN   Name=CHH2;
OS   Penaeus monodon (Giant tiger prawn).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6687;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=10804243; DOI=10.1007/s101269900011;
RA   Davey M.L., Hall M.R., Willis R.H., Oliver R.W.A., Thurn M.J., Wilson K.J.;
RT   "Five crustacean hyperglycemic family hormones of Penaeus monodon:
RT   complementary DNA sequence and identification in single sinus glands by
RT   electrospray ionization-Fourier transform mass spectrometry.";
RL   Mar. Biotechnol. 2:80-91(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 50-118.
RA   Chen H.-Y., Cheng J.-H., Huang C.-J.;
RT   "Molecular cloning and sequence analysis of cDNAs encoding crustacean
RT   hyperglycemic hormone-like neuropeptides from the tiger prawn Penaeus
RT   monodon.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; AF104387; AAC84143.1; -; mRNA.
DR   EMBL; AF104931; AAD03607.1; -; mRNA.
DR   AlphaFoldDB; O97384; -.
DR   SMR; O97384; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   3: Inferred from homology;
KW   Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..42
FT                   /note="CHH precursor-related peptide 2"
FT                   /id="PRO_0000019063"
FT   PEPTIDE         45..116
FT                   /note="Crustacean hyperglycemic hormone 2"
FT                   /id="PRO_0000019064"
FT   MOD_RES         116
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..83
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..96
FT                   /evidence="ECO:0000250"
FT   CONFLICT        52
FT                   /note="A -> K (in Ref. 2; AAD03607)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        56
FT                   /note="N -> D (in Ref. 2; AAD03607)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        62
FT                   /note="R -> G (in Ref. 2; AAD03607)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="P -> S (in Ref. 2; AAD03607)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   118 AA;  13137 MW;  FB6D0A52BDEBCBD9 CRC64;
     MTAFRLVAVA LVVVVACSTT WARSLEGSSS PVASLIRGRS LSKRANFDPS CAGVYNRELL
     GRLSRLCDDC YNVFREPKVA TECRSNCFYN PVFVQCLEYL IPADLHEEYQ AHVQTVGK