ID   CHH3_PENJP              Reviewed;         117 AA.
AC   Q94676;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Crustacean hyperglycemic hormones 3;
DE   AltName: Full=Pej-SGP-III;
DE   Contains:
DE     RecName: Full=CHH precursor-related peptide 3;
DE              Short=CPRP 3;
DE   Contains:
DE     RecName: Full=Crustacean hyperglycemic hormone 3;
DE              Short=CHH 3;
DE   Flags: Precursor;
OS   Penaeus japonicus (Kuruma prawn) (Marsupenaeus japonicus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=27405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=9116871;
RA   Ohira T., Watanabe T., Nagasawa H., Aida K.;
RT   "Cloning and sequence analysis of a cDNA encoding a crustacean
RT   hyperglycemic hormone from the Kuruma prawn Penaeus japonicus.";
RL   Mol. Mar. Biol. Biotechnol. 6:59-63(1997).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; D87864; BAA13481.1; -; mRNA.
DR   AlphaFoldDB; Q94676; -.
DR   SMR; Q94676; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..41
FT                   /note="CHH precursor-related peptide 3"
FT                   /id="PRO_0000019055"
FT   PEPTIDE         44..115
FT                   /note="Crustacean hyperglycemic hormone 3"
FT                   /id="PRO_0000019056"
FT   MOD_RES         115
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..95
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   117 AA;  12954 MW;  BB5841A6F13F6728 CRC64;
     MVTPRMLSAL SAVLLLVLTA SSSARSFDAS PSATSGNHSL NKRSLFDPAC TGIYDRQLLR
     KLGRLCDDCY NVFREPKVAT GCRSNCYHNL IFLDCLEYLI PSHLQEEHMA AMQTVGK