ID   CHHB_METEN              Reviewed;         113 AA.
AC   Q9NGP0;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Crustacean hyperglycemic hormones B;
DE   AltName: Full=MeCHH-B;
DE            Short=CHH-B;
DE   Contains:
DE     RecName: Full=CHH precursor-related peptide B;
DE              Short=CPRP B;
DE   Contains:
DE     RecName: Full=Crustacean hyperglycemic hormone B;
DE              Short=CHH B;
DE   Flags: Precursor;
OS   Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Metapenaeus.
OX   NCBI_TaxID=32278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10781818; DOI=10.1016/s0014-5793(00)01420-4;
RA   Gu P.-L., Yu K.L., Chan S.-M.;
RT   "Molecular characterization of an additional shrimp hyperglycemic hormone:
RT   cDNA cloning, gene organization, expression and biological assay of
RT   recombinant proteins.";
RL   FEBS Lett. 472:122-128(2000).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed at a constant level in the eyestalks of
CC       juveniles and mature females. A low level expression is seen in the
CC       central nervous system.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; AF247160; AAF63028.1; -; mRNA.
DR   AlphaFoldDB; Q9NGP0; -.
DR   SMR; Q9NGP0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         27..37
FT                   /note="CHH precursor-related peptide B"
FT                   /id="PRO_0000019045"
FT   PEPTIDE         40..111
FT                   /note="Crustacean hyperglycemic hormone B"
FT                   /id="PRO_0000019046"
FT   MOD_RES         111
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12937 MW;  9D31AD70084620FA CRC64;
     MVAFRMMSMA LLVVVASSWW ASPVEAASSP RVDHRLVRRS LFDPSCTGVF DRELLGRLNR
     VCDDCYNVFR EPKVATECRS HCFLNPAFIQ CLEYIIPEVL HEEYQANVQL VGK