CHH_ARMVU
ID CHH_ARMVU Reviewed; 73 AA.
AC P30814;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Crustacean hyperglycemic hormone;
DE Short=CHH;
OS Armadillidium vulgare (Pillbug) (Pill woodlouse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC Armadillidiidae; Armadillidium.
OX NCBI_TaxID=13347;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, DISULFIDE BONDS, AND AMIDATION AT
RP SER-73.
RC TISSUE=Sinus gland;
RX PubMed=8436119; DOI=10.1111/j.1432-1033.1993.tb17587.x;
RA Martin G., Sorokine O., van Dorsselaer A.;
RT "Isolation and molecular characterization of a hyperglycemic neuropeptide
RT from the sinus gland of the terrestrial isopod Armadillidium vulgare
RT (Crustacea).";
RL Eur. J. Biochem. 211:601-607(1993).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=12679090; DOI=10.1016/s0016-6480(02)00645-7;
RA Azzouna A., Philippe M., Jarry T., Greve P., Martin G.;
RT "Localization of crustacean hyperglycemic and vitellogenesis-inhibiting
RT hormones in separate cell types in the protocerebrum of the woodlouse
RT Armadillidium vulgare (Crustacea, Isopoda).";
RL Gen. Comp. Endocrinol. 131:134-142(2003).
CC -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC which controls the blood sugar level. Has a secretagogue action over
CC the amylase released from the midgut gland. May act as a stress hormone
CC and may be involved in the control of molting and reproduction.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC eyestalks and transported to the sinus gland where they are stored and
CC released. Found also in the brain; in the neuroendocrine structures of
CC the protocerebrum. {ECO:0000269|PubMed:12679090}.
CC -!- MASS SPECTROMETRY: Mass=8730.2; Mass_error=2; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:8436119};
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR PIR; S29776; S29776.
DR AlphaFoldDB; P30814; -.
DR SMR; P30814; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR000346; Hyperglycemic1.
DR PANTHER; PTHR35981; PTHR35981; 1.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00548; HYPRGLYCEMC1.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 1: Evidence at protein level;
KW Amidation; Carbohydrate metabolism; Direct protein sequencing;
KW Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted.
FT CHAIN 1..73
FT /note="Crustacean hyperglycemic hormone"
FT /id="PRO_0000209852"
FT MOD_RES 73
FT /note="Serine amide"
FT /evidence="ECO:0000269|PubMed:8436119"
FT DISULFID 7..43
FT /evidence="ECO:0000269|PubMed:8436119"
FT DISULFID 23..39
FT /evidence="ECO:0000269|PubMed:8436119"
FT DISULFID 26..52
FT /evidence="ECO:0000269|PubMed:8436119"
SQ SEQUENCE 73 AA; 8736 MW; 21B6DCA38E9F1410 CRC64;
RIFDTSCKGF YDRGLFAQLD RVCEDCYNLY RKPHVAAECR RDCYTTEVFE SCLKDLMMHD
FINEYKEMAL MVS
