ID   CHH_ASTAS               Reviewed;          72 AA.
AC   P83800;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Crustacean hyperglycemic hormone;
DE            Short=CHH;
OS   Astacus astacus (Noble crayfish) (Astacus fluviatilis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Astacidae; Astacus.
OX   NCBI_TaxID=6715 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1, D-AMINO ACID AT PHE-3, AND
RP   AMIDATION AT VAL-72.
RC   TISSUE=Sinus gland {ECO:0000305};
RA   Schmitz T., Bulau P., Peter-Katalinic J., Keller R.;
RL   Submitted (FEB-2004) to UniProtKB.
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC       {ECO:0000250|UniProtKB:P55845, ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=8401.67; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P83800; -.
DR   SMR; P83800; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; D-amino acid;
KW   Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Secreted.
FT   CHAIN           1..72
FT                   /note="Crustacean hyperglycemic hormone"
FT                   /id="PRO_0000209853"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         3
FT                   /note="D-phenylalanine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         72
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        7..43
FT                   /evidence="ECO:0000250|UniProtKB:P55845"
FT   DISULFID        23..39
FT                   /evidence="ECO:0000250|UniProtKB:P55845"
FT   DISULFID        26..52
FT                   /evidence="ECO:0000250|UniProtKB:P55845"
SQ   SEQUENCE   72 AA;  8409 MW;  D638832940AD4DE3 CRC64;
     QVFDQACKGI YDRAIFKKLD RVCDDCYNLY RKPYVATTCR QNCYANSVFR QCLDDLLLID
     VVDEYISGVQ IV