ID   CHH_CANPG               Reviewed;          72 AA.
AC   P81032;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Crustacean hyperglycemic hormone;
DE            Short=CHH;
OS   Cancer pagurus (Rock crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Cancroidea; Cancridae; Cancer.
OX   NCBI_TaxID=6755;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   VAL-72.
RC   TISSUE=Sinus gland;
RX   PubMed=9809792; DOI=10.1016/s0167-0115(98)00024-x;
RA   Chung J.S., Wilkinson M.C., Webster S.G.;
RT   "Amino acid sequences of both isoforms of crustacean hyperglycemic hormone
RT   (CHH) and corresponding precursor-related peptide in Cancer pagurus.";
RL   Regul. Pept. 77:17-24(1998).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released.
CC   -!- PTM: The N-terminus forms pyrrolidone carboxylic acid in isoform CHH-II
CC       and is free in isoform CHH-I.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P81032; -.
DR   SMR; P81032; -.
DR   PRIDE; P81032; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; Direct protein sequencing;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   CHAIN           1..72
FT                   /note="Crustacean hyperglycemic hormone"
FT                   /id="PRO_0000209854"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid; partial"
FT                   /evidence="ECO:0000269|PubMed:9809792"
FT   MOD_RES         72
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:9809792"
FT   DISULFID        7..43
FT   DISULFID        23..39
FT   DISULFID        26..52
SQ   SEQUENCE   72 AA;  8442 MW;  79DF98321F1AAE01 CRC64;
     QIYDTSCKGV YDRGLFSDLE HVCDDCYNLY RNSYVASACR SNCYSNVVFR QCMEELLLMD
     EFDKYARAVQ IV