CHH_CARMA
ID CHH_CARMA Reviewed; 142 AA.
AC P14944;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Crustacean hyperglycemic hormones;
DE Contains:
DE RecName: Full=CHH precursor-related peptide;
DE Short=CPRP;
DE Contains:
DE RecName: Full=Crustacean hyperglycemic hormone;
DE Short=CHH;
DE Flags: Precursor;
OS Carcinus maenas (Common shore crab) (Green crab).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Portunoidea; Carcinidae; Carcinus.
OX NCBI_TaxID=6759;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eyestalk;
RX PubMed=2806562; DOI=10.1016/0014-5793(89)81778-8;
RA Weidemann W., Gromoll J., Keller R.;
RT "Cloning and sequence analysis of cDNA for precursor of a crustacean
RT hyperglycemic hormone.";
RL FEBS Lett. 257:31-34(1989).
RN [2]
RP PROTEIN SEQUENCE OF 67-138, PYROGLUTAMATE FORMATION AT GLN-67, AMIDATION AT
RP VAL-138, AND DISULFIDE BONDS.
RX PubMed=2792364; DOI=10.1016/0014-5793(89)81051-8;
RA Kegel G., Reichwein B., Weese S., Gaus G., Peter-Katalinic J., Keller R.;
RT "Amino acid sequence of the crustacean hyperglycemic hormone (CHH) from the
RT shore crab, Carcinus maenas.";
RL FEBS Lett. 255:10-14(1989).
RN [3]
RP PROTEIN SEQUENCE OF 27-64.
RC TISSUE=Sinus gland;
RX PubMed=1788131; DOI=10.1016/0196-9781(91)90119-a;
RA Tensen C.P., Verhoeven A.H.M., Gaus G., Janssen K.P.C., Keller R.,
RA van Herp F.;
RT "Isolation and amino acid sequence of crustacean hyperglycemic hormone
RT precursor-related peptides.";
RL Peptides 12:673-681(1991).
RN [4]
RP PROTEIN SEQUENCE OF 67-138, AND MASS SPECTROMETRY.
RX PubMed=8841399; DOI=10.1111/j.1432-1033.1996.0358h.x;
RA Chung J.S., Webster S.G.;
RT "Does the N-terminal pyroglutamate residue have any physiological
RT significance for crab hyperglycemic neuropeptides?";
RL Eur. J. Biochem. 240:358-364(1996).
CC -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC which controls the blood sugar level. Has a secretagogue action over
CC the amylase released from the midgut gland. May act as a stress hormone
CC and may be involved in the control of molting and reproduction.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC eyestalks and transported to the sinus gland where they are stored and
CC released.
CC -!- PTM: The N-terminus is blocked only in isoform CHH-II but not in
CC isoform CHH-I.
CC -!- MASS SPECTROMETRY: [Crustacean hyperglycemic hormone]: Mass=8538.3;
CC Mass_error=1; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:8841399};
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR EMBL; X17596; CAA35605.1; -; mRNA.
DR PIR; S06630; S06630.
DR AlphaFoldDB; P14944; -.
DR SMR; P14944; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR005558; Crust_neurhormone_H.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR000346; Hyperglycemic1.
DR PANTHER; PTHR35981; PTHR35981; 1.
DR Pfam; PF03858; Crust_neuro_H; 1.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00548; HYPRGLYCEMC1.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 1: Evidence at protein level;
KW Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone;
KW Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:1788131"
FT PEPTIDE 27..64
FT /note="CHH precursor-related peptide"
FT /id="PRO_0000019037"
FT PEPTIDE 67..138
FT /note="Crustacean hyperglycemic hormone"
FT /id="PRO_0000019038"
FT MOD_RES 67
FT /note="Pyrrolidone carboxylic acid; partial"
FT /evidence="ECO:0000269|PubMed:2792364"
FT MOD_RES 138
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:2792364"
FT DISULFID 73..109
FT /evidence="ECO:0000269|PubMed:2792364"
FT DISULFID 89..105
FT /evidence="ECO:0000269|PubMed:2792364"
FT DISULFID 92..118
FT /evidence="ECO:0000269|PubMed:2792364"
FT CONFLICT 56..57
FT /note="EN -> QH (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 16138 MW; 459F1690BA550372 CRC64;
MYSKTIPAML AIITVAYLCA LPHAHARSTQ GYGRMDRILA ALKTSPMEPS AALAVENGTT
HPLEKRQIYD TSCKGVYDRA LFNDLEHVCD DCYNLYRTSY VASACRSNCY SNLVFRQCMD
DLLMMDEFDQ YARKVQMVGR KK
