ID   CHH_JASLA               Reviewed;          73 AA.
AC   P56687;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Crustacean hyperglycemic hormone;
DE            Short=CHH;
DE   AltName: Full=JAL-CHH-I;
OS   Jasus lalandii (South African spiny lobster).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Achelata;
OC   Palinuroidea; Palinuridae; Jasus.
OX   NCBI_TaxID=99572;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT VAL-73.
RC   TISSUE=Sinus gland;
RX   PubMed=9703969; DOI=10.1006/bbrc.1998.9025;
RA   Marco H.G., Brandt W., Gade G.;
RT   "Elucidation of the amino acid sequence of a crustacean hyperglycaemic
RT   hormone from the spiny lobster, Jasus lalandii.";
RL   Biochem. Biophys. Res. Commun. 248:578-583(1998).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P56687; -.
DR   SMR; P56687; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; Direct protein sequencing;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..73
FT                   /note="Crustacean hyperglycemic hormone"
FT                   /id="PRO_0000209857"
FT   MOD_RES         73
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:9703969"
FT   DISULFID        7..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  8550 MW;  AAC601473DE4ABF0 CRC64;
     AVFDQSCKGV YDRSLFSKLD RVCDDCYNLY RKHYVATGCR RNCYGNLVFR QCLDDLMLVD
     VVDEYYVASV QMV